The Prognostic Value of Advanced Lung Cancer Inflammation Index in Elderly Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

IF 1.2 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS International heart journal Pub Date : 2024-07-13 DOI:10.1536/ihj.24-046

Guoying Zhao, Wenbin Tang, Chao Yang, Xiao Liu, Jinyu Huang

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Abstract

This study aimed to investigate the predictive value of advanced lung cancer inflammation index (ALI) for major adverse cardiovascular events (MACEs) in elderly patients with acute coronary syndrome (ACS).

A total of 586 ACS patients undergoing percutaneous coronary intervention (PCI) over 65 years old between January 2017 and December 2018 were retrospectively collected. The patients were divided into two groups by the optimal cutoff value of ALI. Spearman rank correlation coefficient was used to evaluate the correlation between ALI and the Global Registry of Acute Coronary Events (GRACE). Time-dependent receiver operating characteristic (ROC) curves, Cox survival analysis, and Kaplan Meier curves were used to assess the predictive value of ALI for MACEs.

Spearman's nonparametric test revealed a moderate correlation between ALI and the GRACE (r: −0.417, P < 0.001). Time-dependent ROC curves showed that the area under the curve for ALI was 0.751 (95% CI, 0.699-0.798) in predicting MACEs, higher than Geriatric Nutritional Risk Index (0.531, 95% CI 0.435-0.627) and Prognostic Nutritional Index (0.590, 95% CI 0.505 - 0.676), and for combined diagnostic models (ALI + GRACE) was 0.913, (95% CI 0.875 - 0.942, P < 0.001). Multivariate Cox analysis demonstrated that ALI (HR: 0.974, 95% CI: 0.952-0.996, P = 0.017) was an independent risk factor for MACEs. Kaplan Meier survival analysis showed that the cumulative incidence of MACEs was significantly higher in elderly ACS patients with lower ALI (log-rank test, P < 0.001).

ALI could be a nutrition-inflammation indicator with independent predictive value for long-term MACEs of elderly ACS patients after PCI.

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接受经皮冠状动脉介入治疗的急性冠状动脉综合征老年患者的晚期肺癌炎症指数的预后价值

这项研究旨在探讨晚期肺癌炎症指数（ALI）对老年急性冠状动脉综合征（ACS）患者主要不良心血管事件（MACE）的预测价值。研究人员回顾性收集了2017年1月至2018年12月期间接受经皮冠状动脉介入治疗（PCI）的65岁以上ACS患者共586例。按照ALI的最佳临界值将患者分为两组。斯皮尔曼秩相关系数用于评估ALI与全球急性冠脉事件登记（GRACE）之间的相关性。Spearman非参数检验显示，ALI与GRACE之间存在中度相关性（r：-0.417，P <0.001）。时间依赖性 ROC 曲线显示，ALI 预测 MACE 的曲线下面积为 0.751（95% CI，0.699-0.798），高于老年营养风险指数（0.531，95% CI 0.435-0.627）和预后营养指数（0.590，95% CI 0.505 - 0.676），联合诊断模型（ALI + GRACE）为 0.913，（95% CI 0.875 - 0.942，P <0.001）。多变量 Cox 分析显示，ALI（HR：0.974，95% CI：0.952-0.996，P = 0.017）是 MACEs 的独立危险因素。Kaplan Meier生存分析显示，ALI较低的老年ACS患者的MACE累积发生率明显更高（对数秩检验，P < 0.001）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International heart journal 医学-心血管系统

CiteScore

2.50

自引率

6.70%

发文量

148

审稿时长

6-12 weeks

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