Lifetime Induced Abortions and Live Births: A 40-Year Historical Cohort Study

IF 2 Q2 OBSTETRICS & GYNECOLOGY Journal of obstetrics and gynaecology Canada Pub Date : 2024-07-14 DOI:10.1016/j.jogc.2024.102612
Øjvind Lidegaard MD, DMSci , Hjarn V. Zernichow Borberg MEcon , Steen C. Rasmussen MSci, MPH , Anders P. Mikkelsen MD, PhD
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Abstract

Objectives

Little is known about whether induced abortions are associated with the final lifetime number of live births (life births). The objective of this study was to examine the association between the number of life births with the number of abortions a female has had in her lifetime.

Methods

In a national cohort design, we followed all Danish females from ages 15 to 44 years through the period 1977–2017 for induced abortions and live births. For each lifetime number of induced abortions, the average number of life births was assessed, and rates with 95% CI were calculated.

Results

The study included 409 497 females who completed 222 482 induced abortions and 831 742 live births. Of 265 573 (64.9%) females who did not have any induced abortion, the average number of life births was 2.09 (95% CI 2.08–2.10). For females with 1 (23.4%), 2 (7.4%), 3 (2.6%), 4 (1.0%), and ≥5 (0.7%) induced abortions during their reproductive lifespan, the average number of life births was 1.88 (1.87–1.89), 1.99 (1.98–2.00), 2.09 (2.06–2.11), 2.13 (2.09–2.15), and 2.25 (2.21–2.29), respectively. The increase in number of life births in females with 1 to females with 5+ induced abortions was 4.7% for each additional induced abortion.

Conclusion

We found the number of induced abortions during a woman’s reproductive lifespan to be positively correlated to the number of live births. This association is likely explained by a high fecundity in females with multiple pregnancies including induced abortions and suggests that even several induced abortions do not compromise a woman’s general reproductive end points.

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终生人工流产和活产。40 年历史队列研究。
目的:关于人工流产是否与女性一生中的最终活产数(活产数)有关,人们知之甚少。本研究旨在探讨活产数与女性一生中人工流产次数的关系:在全国队列设计中,我们对 1977-2017 年期间 15 至 44 岁的所有丹麦女性进行了人工流产和活产跟踪调查。对每一生的人工流产次数、平均活产次数进行了评估,并计算了比率和 95% 的置信区间:研究包括 409 497 名女性,她们完成了 222 482 次人工流产和 831 742 次活产。在 265 573 名(64.9%)未进行人工流产的女性中,平均活产数为 2.09(95% CI 2.08-2.10)。在生育期内分别进行过 1 次(23.4%)、2 次(7.4%)、3 次(2.6%)、4 次(1.0%)和≥5 次(0.7%)人工流产的女性的平均生育次数分别为 1.88(1.87-1.89)、1.99(1.98-2.00)、2.09(2.06-2.11)、2.13(2.09-2.15)和 2.25(2.21-2.29)。从人工流产 1 次到人工流产 5 次以上的女性中,每增加一次人工流产,胎儿出生数就增加 4.7%:我们发现,女性生育期内的人工流产次数与活产次数呈正相关。这种关联可能是由于多次妊娠(包括人工流产)的女性生育率较高,并表明即使多次人工流产也不会影响女性的总体生殖终点。
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来源期刊
CiteScore
3.30
自引率
5.60%
发文量
302
审稿时长
32 days
期刊介绍: Journal of Obstetrics and Gynaecology Canada (JOGC) is Canada"s peer-reviewed journal of obstetrics, gynaecology, and women"s health. Each monthly issue contains original research articles, reviews, case reports, commentaries, and editorials on all aspects of reproductive health. JOGC is the original publication source of evidence-based clinical guidelines, committee opinions, and policy statements that derive from standing or ad hoc committees of the Society of Obstetricians and Gynaecologists of Canada. JOGC is included in the National Library of Medicine"s MEDLINE database, and abstracts from JOGC are accessible on PubMed.
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