Consensus recommendations for use of long-acting antiretroviral medications in the treatment and prevention of HIV-1: Endorsed by the American Academy of HIV Medicine, American College of Clinical Pharmacy, Canadian HIV and Viral Hepatitis Pharmacists Network, European AIDS Clinical Society, and Society of Infectious Diseases Pharmacists: An executive summary.

IF 2.9 3区医学 Q2 PHARMACOLOGY & PHARMACY Pharmacotherapy Pub Date : 2024-07-01 DOI:10.1002/phar.2921

Elizabeth M Sherman, Allison L Agwu, Juan Ambrosioni, Georg M N Behrens, Carolyn Chu, Lauren F Collins, Humberto R Jimenez, David E Koren, Leslie McGorman, Nancy N Nguyen, Melanie R Nicol, Neha Sheth Pandit, Natacha Pierre, Kimberly K Scarsi, Gary F Spinner, Alice Tseng, Jeremy D Young, Melissa E Badowski

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Abstract

Five long-acting (LA) antiretrovirals (ARVs) are currently available in a limited number of countries worldwide for HIV-1 prevention or treatment - cabotegravir, rilpivirine, lenacapavir, ibalizumab, and dapivirine. Implementing use of LA ARVs in routine clinical practice requires significant changes to the current framework of HIV-1 prevention, treatment, and service provision. Given the novelty, complexity, and interdisciplinary requirements of safe and optimal use of LA ARVs, consensus recommendations on the use of LA ARVs will assist clinicians in optimizing use of these agents. The purpose of these recommendations is to provide guidance for the clinical use of LA ARVs for HIV-1 treatment and prevention. In addition, future areas of research are identified and discussed.

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在治疗和预防 HIV-1 中使用长效抗逆转录病毒药物的共识建议：经美国艾滋病医学学会、美国临床药学院、加拿大艾滋病和病毒性肝炎药剂师网络、欧洲艾滋病临床学会和传染病药剂师学会认可：执行摘要。

目前，世界上有五种长效（LA）抗逆转录病毒药物（ARV）可在少数国家用于预防或治疗 HIV-1，它们是卡博替拉韦（cabotegravir）、利匹韦林（rilpivirine）、来那卡韦（lenacapavir）、伊巴珠单抗（ibalizumab）和达匹韦林（dapivirine）。在常规临床实践中使用 LA 抗逆转录病毒药物需要对当前的 HIV-1 预防、治疗和服务提供框架进行重大变革。鉴于 LA 抗逆转录病毒药物的新颖性、复杂性以及安全和最佳使用 LA 抗逆转录病毒药物的跨学科要求，有关 LA 抗逆转录病毒药物使用的共识建议将有助于临床医生优化这些药物的使用。这些建议旨在为临床使用 LA 抗逆转录病毒药物治疗和预防 HIV-1 提供指导。此外，还确定并讨论了未来的研究领域。

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来源期刊

Pharmacotherapy 医学-药学

CiteScore

7.80

自引率

2.40%

发文量

审稿时长

4-8 weeks

期刊介绍： Pharmacotherapy is devoted to publication of original research articles on all aspects of human pharmacology and review articles on drugs and drug therapy. The Editors and Editorial Board invite original research reports on pharmacokinetic, bioavailability, and drug interaction studies, clinical trials, investigations of specific pharmacological properties of drugs, and related topics.