Blood eosinophilia and a higher ethmoid sinus/maxillary sinus score ratio predict new-onset asthma in patients with chronic rhinosinusitis with nasal polyps.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-01 Epub Date: 2024-07-16 DOI:10.1080/00016489.2024.2362776

Kun Du, Zhihui Pang, Hongfei Lou, Hongmeng Yu

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Abstract

Backgroud: Presently, the impact of Chronic rhinosinusitis with nasal polyps (CRSwNP) on asthma onset is unknown.

Aims: To evaluate the role of CRSwNP in asthma onset.

Materials and methods: A total of 3107 CRSwNP patients were retrospectively screened from 1 January 2018, to 31 May 2021; 624 patients were enrolled. Clinical data regarding nasal symptoms, Lund-Mackay scores, blood eosinophil percentage, and onset of asthma were analyzed. Patients were divided into different groups according to past history of nasal polyps, Lund-Mackay score, and the extent of blood eosinophilia. Asthma-free rates between these subgroups were analyzed by Kaplan-Meier curves and Cox regression models.

Results: The prevalence of asthma was 10.90% in patients with CRSwNP, and new-onset asthma occurred in 3.14% of these patients. Higher Lund-Mackay scores for ethmoid sinus and maxillary sinus (E/M) and blood eosinophil percentages were two independent risk factors for new-onset asthma, with hazard ratios of 1.267 (95%CI, 1.155-1.390) and 1.224 (95%CI, 1.054-1.422), respectively. CRSwNP patients with an E/M ratio > 2.33 or a blood Eos percentage > 5.5% were at risk for asthma onset.

Conclusions and significance: Blood eosinophilia and a higher E/M score ratio were associated with new-onset asthma in patients with CRSwNP.

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血液嗜酸性粒细胞增多和较高的乙状窦/上颌窦评分比率可预测伴有鼻息肉的慢性鼻窦炎患者新发哮喘。

背景：目前，慢性鼻炎伴鼻息肉（CRSwNP）对哮喘发病的影响尚不清楚。目的：评估CRSwNP在哮喘发病中的作用：回顾性筛查了2018年1月1日至2021年5月31日期间的3107名CRSwNP患者，其中624名患者入选。分析了有关鼻部症状、Lund-Mackay 评分、血液中嗜酸性粒细胞百分比和哮喘发病的临床数据。根据鼻息肉既往史、Lund-Mackay 评分和血液嗜酸性粒细胞增多程度将患者分为不同组别。通过 Kaplan-Meier 曲线和 Cox 回归模型对这些分组之间的无哮喘率进行了分析：结果：CRSwNP 患者的哮喘发病率为 10.90%，其中 3.14% 的患者为新发哮喘。乙状窦和上颌窦（E/M）的伦德-马凯评分较高和血液中嗜酸性粒细胞百分比较高是新发哮喘的两个独立风险因素，危险比分别为 1.267（95%CI，1.155-1.390）和 1.224（95%CI，1.054-1.422）。E/M比值大于2.33或血液中嗜酸性粒细胞百分比大于5.5%的CRSwNP患者有哮喘发病风险：结论与意义：血液嗜酸性粒细胞增多和较高的 E/M 评分比率与 CRSwNP 患者新发哮喘有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.