Ion Channels Remodeling in the Regulation of Vascular Hyporesponsiveness During Shock

IF 1.9 4区 医学 Q3 HEMATOLOGY Microcirculation Pub Date : 2024-07-16 DOI:10.1111/micc.12874
Keqing Li, Yuan Li, Yinghong Chen, Tangting Chen, Yan Yang, Pengyun Li
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Abstract

Shock is characterized with vascular hyporesponsiveness to vasoconstrictors, thereby to cause refractory hypotension, insufficient tissue perfusion, and multiple organ dysfunction. The vascular hyporeactivity persisted even though norepinephrine and fluid resuscitation were administrated, it is of critical importance to find new potential target. Ion channels are crucial in the regulation of cell membrane potential and affect vasoconstriction and vasodilation. It has been demonstrated that many types of ion channels including K+ channels, Ca2+ permeable channels, and Na+ channels exist in vascular smooth muscle cells and endothelial cells, contributing to the regulation of vascular homeostasis and vasomotor function. An increasing number of studies suggested that the structural and functional alterations of ion channels located in arteries contribute to vascular hyporesponsiveness during shock, but the underlying mechanisms remained to be fully clarified. Therefore, the expression and functional changes in ion channels in arteries associated with shock are reviewed, to pave the way for further exploring the potential of ion channel-targeted compounds in treating refractory hypotension in shock.

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离子通道重塑对休克期间血管低反应性的调节作用
休克的特点是血管对血管收缩剂反应迟钝,从而导致难治性低血压、组织灌注不足和多器官功能障碍。因此,寻找新的潜在靶点至关重要。离子通道是调节细胞膜电位的关键,影响着血管收缩和扩张。研究表明,血管平滑肌细胞和内皮细胞中存在多种类型的离子通道,包括 K+ 通道、Ca2+ 通透性通道和 Na+ 通道,它们在调节血管稳态和血管运动功能方面做出了贡献。越来越多的研究表明,位于动脉中的离子通道的结构和功能改变导致了休克时血管的低反应性,但其潜在机制仍有待完全阐明。因此,本文综述了与休克有关的动脉中离子通道的表达和功能变化,为进一步探索离子通道靶向化合物治疗休克难治性低血压的潜力铺平了道路。
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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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