Unexpected Vision Loss following Six Intravitreal Injections for Neovascular Age-Related Macular Degeneration.

IF 0.6 Q4 OPHTHALMOLOGY Case Reports in Ophthalmology Pub Date : 2024-06-28 eCollection Date: 2024-01-01 DOI:10.1159/000537777

Maggie Hui, Robert Gunzenhauser, Alexander Dillon, Irena Tsui

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Abstract

Introduction: We present a case of a patient with preceding vitreomacular traction (VMT) who developed a full-thickness macular hole (FTMH) following his sixth intravitreal aflibercept injection for the treatment of age-related macular degeneration and review the literature on risk factors and pathogenesis of this adverse event.

Case presentation: FTMH can occur after an extended number of repeat intravitreal injections in the setting of worsening vitreomacular adhesion or VMT. This patient's FTMH was successfully treated surgically in a timely manner, and additional injections were resumed safely.

Conclusions: Patients with an unexpected decrease in vision after intravitreal injections should be reevaluated with optical coherence tomography to rule out alternative pathology including vitreomacular interface abnormalities. FTMH, if present, should be treated promptly to allow for resumption of therapy as needed and visual optimization.

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对新生血管性老年性黄斑变性进行六次玻璃体内注射后的意外视力损失。

导言：我们介绍了一例曾有玻璃体粘连（VMT）的患者，他在为治疗老年性黄斑变性而进行第六次玻璃体内注射阿夫利拜通（aflibercept）后出现了全厚黄斑孔（FTMH），我们还回顾了有关这一不良事件的风险因素和发病机制的文献：在玻璃体粘连或VMT恶化的情况下，重复多次玻璃体内注射后可能会出现FTMH。该患者的 FTMH 成功地得到了及时的手术治疗，并安全地恢复了额外的注射：结论：玻璃体内注射后视力意外下降的患者应通过光学相干断层扫描重新进行评估，以排除其他病变，包括玻璃体白膜界面异常。如果存在FTMH，应及时治疗，以便根据需要恢复治疗并优化视力。

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来源期刊

Case Reports in Ophthalmology OPHTHALMOLOGY-

CiteScore

0.90

自引率

0.00%

发文量

129

审稿时长

12 weeks

期刊介绍： This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of ophthalmology, including prevention, diagnosis, treatment, toxicities of therapy, supportive care, quality-of-life, and survivorship issues. The submission of negative results is strongly encouraged. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed. The intent of the journal is to provide clinicians and researchers with a tool to disseminate their personal experiences to a wider public as well as to review interesting cases encountered by colleagues all over the world. Universally used terms can be searched across the entire growing collection of case reports, further facilitating the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times.