Long non-coding RNA SNHG7 serves as a diagnostic biomarker for acute coronary syndrome and its predictive value for the clinical outcome after percutaneous coronary intervention.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiothoracic Surgery Pub Date : 2024-07-16 DOI:10.1186/s13019-024-02855-z

Ran Liao, Qing Han, Li Zhang

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引用次数: 0

Abstract

Background: Acute coronary syndrome (ACS) is one of the common causes of cardiovascular death. The related lncRNAs were novel approaches for early diagnosis and intervention. This paper focused on the clinical function of SNHG7 for patients after PCI.

Methods: The expression of SNHG7 was assessed in ACS patients. The predictive roles of SNHG7 were unveiled by the ROC curve. The relationship between SNHG7 and Gensini scores was judged by Pearson analysis. One-year follow-up was conducted and all patients were catalogued into different groups based on the prognosis. The qRT-PCR, K-M curve, and Cox regression analysis were performed to document the prognostic significance of SNHG7.

Results: SNHG7 was highly expressed in ACS and its three subtypes. SNHG7 showed a certain value in predicting ACS, UA, NSTEMI, and STEMI. Gensini is a closely correlated indicator of SNHG7. The declined expression of SNHG7 was observed in the non-MACE and survival groups. The risk of MACE and death was increased in the group with high expression of SNHG7. SNHG7 was an independent biomarker in patients with ACS after PCI.

Conclusions: SNHG7 might be a diagnostic and prognostic tool for ACS patients.

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长非编码 RNA SNHG7 可作为急性冠状动脉综合征的诊断生物标志物，并对经皮冠状动脉介入治疗后的临床结果具有预测价值。

背景：急性冠状动脉综合征（ACS急性冠状动脉综合征（ACS）是心血管疾病死亡的常见原因之一。相关的 lncRNA 是早期诊断和干预的新方法。本文重点研究了SNHG7对PCI术后患者的临床功能：方法：评估 SNHG7 在 ACS 患者中的表达。ROC曲线揭示了SNHG7的预测作用。通过 Pearson 分析判断 SNHG7 与 Gensini 评分之间的关系。对所有患者进行为期一年的随访，并根据预后将其分为不同的组别。通过qRT-PCR、K-M曲线和Cox回归分析，证实了SNHG7的预后意义：结果：SNHG7在ACS及其三个亚型中高表达。SNHG7在预测ACS、UA、NSTEMI和STEMI中有一定价值。Gensini是与SNHG7密切相关的指标。在非 MACE 组和存活组中，SNHG7 的表达下降。SNHG7高表达组发生MACE和死亡的风险增加。SNHG7是PCI术后ACS患者的独立生物标志物：SNHG7可能是ACS患者的诊断和预后工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiothoracic Surgery 医学-心血管系统

CiteScore

2.50

自引率

6.20%

发文量

286

审稿时长

4-8 weeks

期刊介绍： Journal of Cardiothoracic Surgery is an open access journal that encompasses all aspects of research in the field of Cardiology, and Cardiothoracic and Vascular Surgery. The journal publishes original scientific research documenting clinical and experimental advances in cardiac, vascular and thoracic surgery, and related fields. Topics of interest include surgical techniques, survival rates, surgical complications and their outcomes; along with basic sciences, pediatric conditions, transplantations and clinical trials. Journal of Cardiothoracic Surgery is of interest to cardiothoracic and vascular surgeons, cardiothoracic anaesthesiologists, cardiologists, chest physicians, and allied health professionals.