Trimethoprim-sulfamethoxazole acute respiratory distress syndrome requiring lung transplantation.

IF 0.8 Q4 RESPIRATORY SYSTEM Respirology Case Reports Pub Date : 2024-07-15 eCollection Date: 2024-07-01 DOI:10.1002/rcr2.1434
Matthew Donnan, Miranda Siemienowicz, Hui Sien Tay, Catriona McLean, Steve Philpot, Chris Mason, Greg Snell, Ian Glaspole, Rob G Stirling
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Abstract

Trimethoprim-sulfamethoxazole (TMP-SMX) acute respiratory distress syndrome (ARDS) is a rare, but severe complication of a commonly prescribed antibiotic. TMP-SMX typically affects young, otherwise well patients with a specific human leukocyte antigen type (HLA-B*07:02 and HLA-C*07:02). The condition is poorly understood with a unique pathological appearance and mechanism that remains unclear. Mortality rate is greater than one third. We describe the case of a previously well 18-year-old woman treated with a prolonged course of TMP-SMX for a complex urinary tract infection who developed rapidly progressive respiratory failure requiring prolonged intensive care admission, extra-corporeal membranous oxygenation, and eventual lung transplantation. No targeted treatment exists, further research is required to better understand disease pathogenetic mechanisms and potential therapeutic interventions.

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需要进行肺移植的三甲氧苄氨嘧啶-磺胺甲噁唑急性呼吸窘迫综合征。
三甲双胍-磺胺甲噁唑(TMP-SMX)急性呼吸窘迫综合征(ARDS)是一种罕见但严重的常用抗生素并发症。TMP-SMX 通常会影响年轻、身体健康且具有特定人类白细胞抗原类型(HLA-B*07:02 和 HLA-C*07:02)的患者。这种疾病的病理外观和发病机制独特,目前尚不清楚。死亡率超过三分之一。我们描述了这样一个病例:一名曾因复杂性尿路感染接受长期 TMP-SMX 治疗的 18 岁女性患者,因病情发展迅速而出现呼吸衰竭,需要长期入院接受重症监护、体外膜肺氧合治疗,并最终接受肺移植手术。目前尚无有针对性的治疗方法,需要进一步研究,以更好地了解疾病的发病机制和潜在的治疗干预措施。
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来源期刊
Respirology Case Reports
Respirology Case Reports RESPIRATORY SYSTEM-
CiteScore
1.40
自引率
0.00%
发文量
178
审稿时长
8 weeks
期刊介绍: Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.
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