Cardioprotective Effects of 'Vasant Kusumakar Rasa,' a Herbo-metallic Formulation, in Type 2 Diabetic Cardiomyopathy in Rats.

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-07-18 DOI:10.1007/s12012-024-09891-0
Alok D Singh, Mukesh B Chawda, Yogesh A Kulkarni
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Abstract

Diabetic cardiomyopathy (DCM) is one of the serious complications of type 2 diabetes mellitus. Vasant Kusumakar Rasa (VKR) is a Herbo-metallic formulation reported in Ayurveda, an Indian system of medicine. The present work was designed to study the effect of VKR in cardiomyopathy in type 2 diabetic rats. Diabetes was induced by feeding a high-fat diet (HFD) for 2 weeks followed by streptozotocin (STZ) administration (35 mg/kg i.p.). VKR was administered orally at dose of 28 and 56 mg/kg once a day for 16 weeks. The results of the study indicated that VKR treatment significantly improved the glycemic and lipid profile, serum insulin, CK-MB, LDH, and cardiac troponin-I when compared to diabetic control animals. VKR treatment in rats significantly improved the hemodynamic parameters and cardiac tissue levels of TNF-α, IL-1β, and IL- 6 were also reduced. Antioxidant enzymes such as GSH, SOD, and catalase were improved in all treatment groups. Heart sections stained with H & E and Masson's trichome showed decreased damage to histoarchitecture of the myocardium. Expression of PI3K, Akt, and GLUT4 in the myocardium was upregulated after 16 weeks of VKR treatment. The study data suggested the cardioprotective capability of VKR in the management of diabetic cardiomyopathy in rats.

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Vasant Kusumakar Rasa"(一种草药金属配方)对大鼠 2 型糖尿病心肌病的心脏保护作用
糖尿病心肌病(DCM)是 2 型糖尿病的严重并发症之一。Vasant Kusumakar Rasa(VKR)是印度阿育吠陀医学体系中的一种草药金属配方。本研究旨在探讨 VKR 对 2 型糖尿病大鼠心肌病的影响。通过喂食高脂饮食(HFD)2 周诱发糖尿病,然后给予链脲佐菌素(STZ)(35 毫克/千克,静脉注射)。VKR 的口服剂量分别为 28 毫克/千克和 56 毫克/千克,每天一次,持续 16 周。研究结果表明,与糖尿病对照组相比,VKR 治疗能明显改善大鼠的血糖和血脂状况、血清胰岛素、CK-MB、LDH 和心肌肌钙蛋白-I。对大鼠进行 VKR 治疗可明显改善血液动力学参数,并降低心脏组织中 TNF-α、IL-1β 和 IL- 6 的水平。所有治疗组的抗氧化酶,如 GSH、SOD 和过氧化氢酶都有所提高。用 H & E 和 Masson's trichome 染色的心脏切片显示,心肌组织结构的损伤有所减少。VKR 治疗 16 周后,PI3K、Akt 和 GLUT4 在心肌中的表达上调。研究数据表明,VKR 在治疗糖尿病大鼠心肌病方面具有保护心脏的作用。
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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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