90Y SIR-Spheres Activity Measurement with New SIROS D-Vial Delivery Kit.

IF 1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of nuclear medicine technology Pub Date : 2024-09-05 DOI:10.2967/jnmt.124.267413
Benjamin P Lopez, S Cheenu Kappadath
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Abstract

A new 90Y SIR-Spheres delivery kit (SIROS D-vial and shield) has been introduced with a different physical form from the legacy V-Vial kit. Here, we establish the dose calibrator settings and exposure-rate-to-activity conversion factor to assay 90Y SIR-Spheres activity in the new SIROS kit. Methods: Eight D-vials with initial 90Y activities from 1.2 to 6.6 GBq within acrylic shields were assayed with dose calibrators and exposure-rate meters until activities decayed to approximately 0.1 GBq. The dose calibrator settings resulting in the lowest median activity errors and the best-fit slope of exposure rate versus activity were identified. Results: SIROS D-vial 90Y activity can be accurately and reliably estimated directly using setting 51 × 10 on both the CRC-15R and the CRC-55tR dose calibrators (errors within ±0.5%) and indirectly with an exposure-rate reading at 30 cm using conversion factor 0.664 ± 0.003 GBq/(mR/h) (R 2 = 0.985). Conclusion: Dose calibrator settings and exposure-rate-to-activity conversion factor for 90Y activity assays with new SIROS kit should be updated from legacy V-Vial parameters to avoid an approximately 10% underestimation.

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使用新型 SIROS D 瓶输送套件进行 90Y SIR-Spheres 活性测量。
新推出的 90Y SIR-Spheres 运载试剂盒(SIROS D 瓶和防护罩)采用了不同于传统 V 瓶试剂盒的物理形式。在此,我们确定了剂量校准器的设置和曝光率与活性的转换系数,以便在新的 SIROS 套件中检测 90Y SIR-Spheres 活性。方法:使用剂量校准器和曝光率测量仪对丙烯酸防护罩内初始 90Y 放射性活度为 1.2 至 6.6 GBq 的 8 个 D-椭球体进行检测,直到放射性活度衰减到大约 0.1 GBq。确定了能使放射性活度误差中位数最小的剂量校准器设置,以及辐照速率与放射性活度的最佳拟合斜率。结果:使用 CRC-15R 和 CRC-55tR 剂量校准器上的 51 × 10 设置直接估算 SIROS D-vial 90Y 放射性活度(误差在 ±0.5% 以内),使用转换系数 0.664 ± 0.003 GBq/(mR/h) 间接估算 30 厘米处的暴露率读数(R 2 = 0.985)。结论使用新的 SIROS 套件进行 90Y 活性测定时,剂量校准器的设置和曝光率与活性的换算系数应根据原有的 V-Vial 参数进行更新,以避免约 10%的低估。
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来源期刊
Journal of nuclear medicine technology
Journal of nuclear medicine technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.90
自引率
15.40%
发文量
57
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