Plasma p-tau217 concordance with amyloid PET among ethnically diverse older adults.

IF 4 Q1 CLINICAL NEUROLOGY Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2024-07-17 eCollection Date: 2024-07-01 DOI:10.1002/dad2.12617

Breton M Asken, Jesse C DeSimone, Wei-En Wang, Karen N McFarland, Franchesca Arias, Shellie-Anne Levy, Jacob Fiala, Idaly Velez-Uribe, Robin P Mayrand, Luana Okino Sawada, Christian Freytes, Michael Adeyosoye, Warren W Barker, Elizabeth A Crocco, Steven T DeKosky, Malek Adjouadi, Monica Rosselli, Michael Marsiske, Melissa J Armstrong, Glenn E Smith, Rosie Curiel Cid, David A Loewenstein, David E Vaillancourt, Ranjan Duara

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Abstract

Introduction: Commercially available plasma p-tau217 biomarker tests are not well studied in ethnically diverse samples.

Methods: We evaluated associations between ALZPath plasma p-tau217 and amyloid-beta positron emission tomography (Aβ-PET) in Hispanic/Latino (88% of Cuban or South American ancestry) and non-Hispanic/Latino older adults. One- and two-cutoff ranges were derived and evaluated to assess agreement with Aβ-PET.

Results: A total of 239 participants underwent blood draw and Aβ-PET (age 70.8 ± 7.8, 55.2% female, education 15.6 ± 3.4 years, 48.9% Hispanic/Latino, 94.9% white). Plasma p-tau217 showed excellent discrimination of Aβ-PET positive and negative participants (visual read: AUC = 0.91 [0.87-0.95], p < 0.001; Centiloids quantification: AUC = 0.90 [0.86-0.94]). There was a greater percent agreement between low p-tau217 and negative Aβ-PET (95.8%) than high p-tau217 and positive Aβ-PET (86.3%). Analyses within ethnicity-specific subgroups suggested similar p-tau217 performance.

Discussion: Plasma p-tau217 (ALZPath) relates to brain Aβ in Hispanic/Latino and non-Hispanic/Latino older adults. Independent validation and replication are necessary to establish reference ranges and inform appropriate contexts of use across ethno-racially diverse populations.

Highlights: Plasma p-tau217 (ALZPath) and Aβ-PET were measured in Hispanic/Latino and non-Hispanic/Latino older adults.Plasma p-tau217 accurately discriminated Aβ-PET positive and negative participants.Applying a two-cutoff "intermediate" plasma p-tau217 approach could reduce need for more invasive and costly testing.Plasma p-tau217 associations with Aβ-PET were strong within both Hispanic/Latino and non-Hispanic/Latino groups.

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不同种族老年人血浆 p-tau217 与淀粉样蛋白 PET 的一致性。

简介：商业化的血浆 p-tau217 生物标记物检测方法在不同种族样本中的应用还不成熟：市售的血浆 p-tau217 生物标志物检测方法在不同种族的样本中并没有得到很好的研究：我们评估了西班牙裔/拉美裔（88%有古巴或南美血统）和非西班牙裔/拉美裔老年人的ALZPath血浆p-tau217与淀粉样β正电子发射断层扫描（Aβ-PET）之间的关联。得出了一个和两个截断范围，并对其与 Aβ-PET 的一致性进行了评估：共有 239 人接受了抽血和 Aβ-PET 检测（年龄 70.8 ± 7.8，55.2% 为女性，教育程度 15.6 ± 3.4 年，48.9% 为西班牙裔/拉美裔，94.9% 为白人）。血浆 p-tau217 能很好地区分 Aβ-PET 阳性和阴性参与者（目视读数：AUC = 0.91 [0.9] [0.9]）：AUC = 0.91 [0.87-0.95]，p 讨论：在西班牙裔/拉美裔和非西班牙裔/拉美裔老年人中，血浆p-tau217（ALZPath）与脑Aβ有关。有必要进行独立验证和复制，以确定参考范围，并告知不同种族人群的适当使用范围：在西班牙裔/拉美裔和非西班牙裔/拉美裔老年人中测量了血浆p-tau217（ALZPath）和Aβ-PET。血浆p-tau217能准确区分Aβ-PET阳性和阴性参与者。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.