A mechanistic insight into cancer progression mediated by Nucleoporins

IF 1.4 4区医学 Q4 GENETICS & HEREDITY Cancer Genetics Pub Date : 2024-07-14 DOI:10.1016/j.cancergen.2024.07.001

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Abstract

The nuclear pore complexes are essential for cellular and molecular processes such as trafficking between the cytoplasm and the nucleus, chromatin, transcriptional outputs, and DNA damage repair. Nucleoporins, components of nuclear pore complexes, have been linked to cancer through nucleo-cytoplasmic cargo trafficking, cell division, signalling pathways, chromatin-related processes, and protein stability and degradation. This study aims to understand how nucleoporins specifically contribute to cancer proliferation and progression across various cancer types. Accordingly, angles such as nuclear trafficking, fusion proteins, tumour suppressors, signalling pathways, tumour microenvironment, nucleosomes, and chromatin processes were found to bridge the function of nucleoporins and cancer progression, and the underlying mechanisms have been analysed in this study. A deep understanding of the function of nucleoporins in cancer progression will pave the way for the effective targeting of these molecules for therapeutic gain. Improved treatment responses can enhance the quality of life of cancer patients.

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从机理上洞察核蛋白介导的癌症进展

核孔复合体对于细胞和分子过程（如细胞质和细胞核之间的贩运、染色质、转录输出和 DNA 损伤修复）至关重要。核孔复合体的组成成分--核多聚蛋白通过核-细胞质货物运输、细胞分裂、信号通路、染色质相关过程以及蛋白质稳定性和降解与癌症有关。本研究旨在了解核多聚酶如何在各种癌症类型中具体促进癌症的增殖和发展。因此，本研究从核贩运、融合蛋白、肿瘤抑制因子、信号通路、肿瘤微环境、核糖体和染色质过程等角度，发现了核多聚酶的功能与癌症进展之间的联系，并分析了其潜在机制。深入了解核多聚酶在癌症进展中的功能将为有效靶向这些分子以获得治疗收益铺平道路。改善治疗反应可以提高癌症患者的生活质量。

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来源期刊

Cancer Genetics ONCOLOGY-GENETICS & HEREDITY

CiteScore

3.20

自引率

5.30%

发文量

167

审稿时长

27 days

期刊介绍： The aim of Cancer Genetics is to publish high quality scientific papers on the cellular, genetic and molecular aspects of cancer, including cancer predisposition and clinical diagnostic applications. Specific areas of interest include descriptions of new chromosomal, molecular or epigenetic alterations in benign and malignant diseases; novel laboratory approaches for identification and characterization of chromosomal rearrangements or genomic alterations in cancer cells; correlation of genetic changes with pathology and clinical presentation; and the molecular genetics of cancer predisposition. To reach a basic science and clinical multidisciplinary audience, we welcome original full-length articles, reviews, meeting summaries, brief reports, and letters to the editor.