Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS Clinical nutrition Pub Date : 2024-07-14 DOI:10.1016/j.clnu.2024.07.008

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Abstract

Background

Concentrations of vitamin D (VitD) and 25-hydroxyvitamin D (25OHD) in breastmilk are low despite the essential role of VitD for normal infant bone development, yet additional metabolic forms of vitamin D may be present. This study evaluates the contribution of sulfated vitamin D metabolites, vitamin D₃-sulfate (VitD₃-S) and 25-hydroxyvitamin D₃-sulfate (25OHD₃-S) for lactating women and assesses the response to high-dose VitD₃ supplementation.

Methods

Serum and breastmilk were measured before and after 28 days with 5000 IU/day VitD₃ intake in 20 lactating women. Concentrations of VitD₃-S and 25OHD₃-S in milk, and 25OHD₂, 25OHD₃, 25OHD₃-S, VitD₃ and VitD₃-S in serum were determined by mass spectrometry.

Results

Baseline vitamin D status was categorized as sufficient (mean ± SD serum 25OHD₃ 69 ± 19 nmol/L), and both serum VitD₃ and 25OHD₃ increased following supplementation (p < 0.001). 25OHD₃-S was 91 ± 19 nmol/L in serum and 0.47 ± 0.09 nmol/L in breastmilk. VitD₃-S concentrations were 2.92 ± 0.70 nmol/L in serum and 6.4 ± 3.9 nmol/L in breastmilk. Neither sulfated metabolite significantly changed with supplementation in either serum or breastmilk.

Conclusions

Sulfated vitamin D metabolites have prominent roles for women during lactation with 25OHD₃-S highly abundant in serum and VitD₃-S distinctly abundant in breastmilk. These data support the notion that 25OHD₃-S and VitD₃-S may have physiological relevance during lactation and nutritional usage for nursing infants.

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硫酸化维生素 D 代谢物在哺乳期妇女的血清和母乳中发挥着重要作用

背景尽管维生素 D 对婴儿骨骼的正常发育起着至关重要的作用，但母乳中维生素 D (VitD) 和 25- 羟基维生素 D (25OHD) 的浓度却很低，而且还可能存在其他代谢形式的维生素 D。本研究评估了硫酸化维生素 D 代谢物、维生素 D3-硫酸盐（VitD3-S）和 25-羟基维生素 D3-硫酸盐（25OHD3-S）对哺乳期妇女的贡献，并评估了对高剂量 VitD3 补充剂的反应。结果基线维生素 D 状态被归类为充足（平均值 ± SD 血清 25OHD3 69 ± 19 nmol/L），补充维生素 D 后血清 VitD3 和 25OHD3 均有所增加（p < 0.001）。血清中的 25OHD3-S 为 91 ± 19 nmol/L，母乳中为 0.47 ± 0.09 nmol/L。血清中维生素 D3-S 的浓度为 2.92 ± 0.70 nmol/L，母乳中为 6.4 ± 3.9 nmol/L。结论硫酸化维生素 D 代谢物在哺乳期对妇女具有重要作用，25OHD3-S 在血清中含量很高，而 VitD3-S 在母乳中含量明显较高。这些数据支持这样一种观点，即 25OHD3-S 和 VitD3-S 在哺乳期可能具有生理意义，并可为哺乳期婴儿提供营养。

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来源期刊

Clinical nutrition 医学-营养学

CiteScore

14.10

自引率

6.30%

发文量

356

审稿时长

28 days

期刊介绍： Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Published bi-monthly, each issue combines original articles and reviews providing an invaluable reference for any specialist concerned with these fields.