Chemical burn wounds as a risk factor for gastric cancer: in-silico analyses-experimental research

M. Zabihi, Mohammad Akhoondian, Mobina Tohidian, Samad Karkhah, Pooyan Ghorbani Vajargah, Seyed Amirhossein Mazhari, B. Farhadi, R. Farzan
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Abstract

The present study employs bioinformatics tools to identify shared upregulated genes between chemical burns and gastric cancer. GEO retrieved gene sets for this investigation. GSEs with P-value <0.05 and LOG fold change (FC) >1 were valid and upregulated. Gastric cancer and chemical burn common elevated genes were found using Venn diagram online tools. In the second stage, the “string” visualized gastric cancer elevated genes network, and non-coding RNAs were deleted, and “interaction” >1 was examined to choose important gene nodes. Next, they explored the String gene-interaction network for common genes. To determine the most interacting genes, Gephi (V 0.9.7) used “betweenness centrality” > “0” to evaluate the twenty-gene network. TISIDB and drug banks provide gene-related medications. In the present study, two genes, including ALOX5AP and SERPINB2, were obtained, with the highest centrality among chemical burns and gastric cancer shared genes. Additionally, the current study presented five drugs, including Urokinase, Tenecteplase, DG031, AM103, and Fiboflapon, which can have predicted effects on gastric cancer following chemical burns. According to current in-silicon analyses, ALOX5AP and SERPINB2 are linked genetic keys between gastric chemical burn and cancer. Considering that burn is an environmental factor that leads to the upregulation of the two genes thus, the chemical burn can be related to the incidence of gastric cancer.
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化学烧伤是胃癌的危险因素:硅内分析-实验研究
本研究利用生物信息学工具来识别化学烧伤与胃癌之间的共有上调基因。 GEO 为本研究检索了基因集。P 值为 1 的 GSE 为有效上调基因。利用维恩图在线工具找到了胃癌和化学烧伤的共同上调基因。第二阶段,通过 "string "可视化胃癌升高基因网络,删除非编码 RNA,并考察 "interaction">1,以选择重要的基因节点。接下来,他们探索了 "字符串 "基因相互作用网络中的常见基因。为了确定相互作用最多的基因,Gephi(V 0.9.7)使用 "间度中心性">"0 "来评估 20 个基因网络。TISIDB 和药物库提供与基因相关的药物。 本研究获得了两个基因,包括 ALOX5AP 和 SERPINB2,在化学烧伤和胃癌共享基因中中心度最高。此外,本研究还提出了五种药物,包括尿激酶、替奈替普酶、DG031、AM103 和 Fiboflapon,可以预测这些药物对化学烧伤后胃癌的影响。 根据目前的硅内分析,ALOX5AP 和 SERPINB2 是胃化学烧伤与癌症之间的关联基因。考虑到烧伤是导致这两个基因上调的环境因素,因此化学烧伤可能与胃癌的发病率有关。
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