Hydrazide–hydrazones as potential antitubercular agents: overview of the literature (1999-2023)

Abstract

Hydrazide-hydrazone derivatives are prevalent in numerous bioactive compounds, showcasing a diverse array of biological effects including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antiviral, and antiprotozoal properties. Consequently, numerous medicinal chemists undertake the synthesis of various hydrazide-hydrazones, subjecting them to evaluation for their biological activities. Among these, antituberculosis activity stands out as a recurring focus in scientific literature. This paper provides a comprehensive overview of research spanning the last twenty-four years (1999-2023), concentrating on the antituberculosis properties of hydrazide-hydrazone derivatives. The insights presented herein could serve as a valuable roadmap for the development of novel hydrazide-hydrazones with potential antimicrobial efficacy.