The Influence of Growth Hormone and Insulin-like Growth Factor 1 on Anthropometric Parameters in Children with Type 1 Diabetes Mellitus

Abstract

The goal is to study the indicators of somatotropic hormone and insulin-like growth factor-1 to assess the effect on anthropometric indicators of children with type 1 diabetes mellitus. 74 children with type 1 diabetes mellitus and 14 children in the control group were examined. Average age 12±3.5 years. The assessment of physical development was carried out on the basis of an assessment of anthropometric indicators — height and body weight with the calculation of BMI and compared with centile tables. Determination of the concentration of hormones such as GH and IGF-1 was determined by special ELISA kits using the enzyme immunoassay method using an analyzer (Mindray MR-96A). The obtained data were subjected to statistical processing. It was revealed that 8 (36.4%) boys and the majority of girls 14 (63.6%) achieved the target level of glycated hemoglobin. Children with T1DM are statistically significant and stunted in height and weight compared to healthy children in the control group.