Mestet Yibeltal Shiferaw, A. S. Baleh, Abel Gizaw, T. Teklemariam, A. Aklilu, A. Awedew, Denekew Tenaw Anley, Bereket Hailu Mekuria, Ermias Fikru Yesuf, Mengistu Ayele Yigzaw, Henock Teshome Molla, Alemu Adise Mildie, Mekides Musie Awano, Abraham Teym
{"title":"Predictors of Operative Ischemic Cerebrovascular Complications in Skull Base Tumor Resections: Experience in Low Resource Setting","authors":"Mestet Yibeltal Shiferaw, A. S. Baleh, Abel Gizaw, T. Teklemariam, A. Aklilu, A. Awedew, Denekew Tenaw Anley, Bereket Hailu Mekuria, Ermias Fikru Yesuf, Mengistu Ayele Yigzaw, Henock Teshome Molla, Alemu Adise Mildie, Mekides Musie Awano, Abraham Teym","doi":"10.1093/nop/npae063","DOIUrl":null,"url":null,"abstract":"\n \n \n Ischemic cerebrovascular complications following skull base tumor resections remain a significant factor impacting both short-term and long-term patient outcomes. This study aims to improve risk stratification, surgical decision-making and postoperative care protocols.\n \n \n \n A retrospective cohort study on predictors of ischemic cerebrovascular complications among patients who underwent skull base tumor resection was conducted at two high-volume neurosurgical centers in Ethiopia from 2018 - 2023. Binary logistic analysis was performed to see the association of each predictor variable.\n \n \n \n The study included 266 patients, with 65.5% being female. The median age and tumor size were 37 (±IQR=17) years and 4.9cm (± IQR 1.5) respectively. Ischemic cerebrovascular complications occurred in 19.9% of patients. Middle cranial fossa tumors and tumors spanning both anterior & middle cranial fossa (AOR = 6.75, 95% CI 1.66-27.54, p < 0.008), grade 3-5 vascular encasement (AOR = 5.04, 95% CI 1.79-14.12, p < 0.002), near-total resection and gross total resection (AOR = 2.89, 95% CI 1.01-8.24, p <0.048), and difficult hemostasis (AOR = 9.37, 95% CI 3.19-27.52, p < 0.000) were significantly associated with iatrogenic vascular injury. Sub-arachnoid hemorrhage had a statistically significant association with vasospasm (AOR = 12.27, 95% CI: 1.99-75.37, p = 0.007).\n \n \n \n Surgery-related ischemic cerebrovascular complications are common. Thorough perioperative risk stratification and proactive treatment planning are crucial to mitigate vascular insults associated with it. In low-resource settings, neurosurgical services are provided without advanced instruments, leading to more complications. Therefore, it's important to focus on improving neurosurgical setup to enhance patient outcomes.\n","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuro-oncology practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/nop/npae063","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Ischemic cerebrovascular complications following skull base tumor resections remain a significant factor impacting both short-term and long-term patient outcomes. This study aims to improve risk stratification, surgical decision-making and postoperative care protocols.
A retrospective cohort study on predictors of ischemic cerebrovascular complications among patients who underwent skull base tumor resection was conducted at two high-volume neurosurgical centers in Ethiopia from 2018 - 2023. Binary logistic analysis was performed to see the association of each predictor variable.
The study included 266 patients, with 65.5% being female. The median age and tumor size were 37 (±IQR=17) years and 4.9cm (± IQR 1.5) respectively. Ischemic cerebrovascular complications occurred in 19.9% of patients. Middle cranial fossa tumors and tumors spanning both anterior & middle cranial fossa (AOR = 6.75, 95% CI 1.66-27.54, p < 0.008), grade 3-5 vascular encasement (AOR = 5.04, 95% CI 1.79-14.12, p < 0.002), near-total resection and gross total resection (AOR = 2.89, 95% CI 1.01-8.24, p <0.048), and difficult hemostasis (AOR = 9.37, 95% CI 3.19-27.52, p < 0.000) were significantly associated with iatrogenic vascular injury. Sub-arachnoid hemorrhage had a statistically significant association with vasospasm (AOR = 12.27, 95% CI: 1.99-75.37, p = 0.007).
Surgery-related ischemic cerebrovascular complications are common. Thorough perioperative risk stratification and proactive treatment planning are crucial to mitigate vascular insults associated with it. In low-resource settings, neurosurgical services are provided without advanced instruments, leading to more complications. Therefore, it's important to focus on improving neurosurgical setup to enhance patient outcomes.
期刊介绍:
Neuro-Oncology Practice focuses on the clinical aspects of the subspecialty for practicing clinicians and healthcare specialists from a variety of disciplines including physicians, nurses, physical/occupational therapists, neuropsychologists, and palliative care specialists, who have focused their careers on clinical patient care and who want to apply the latest treatment advances to their practice. These include: Applying new trial results to improve standards of patient care Translating scientific advances such as tumor molecular profiling and advanced imaging into clinical treatment decision making and personalized brain tumor therapies Raising awareness of basic, translational and clinical research in areas of symptom management, survivorship, neurocognitive function, end of life issues and caregiving