Mental Manifestations and Biomarkers of Alcohol Consumption

Life Pub Date : 2024-07-12 DOI:10.3390/life14070873
Ana-Maria Sarpe (Paduraru), Cristina Dodul, Emil-Andrei Vlase, Cristian Onisor, E. Niculeț, O. Ciobotaru, Eduard Polea Drima
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Abstract

The purpose of this study is to examine healthcare usage, morbidities, and alcohol consumption monitoring in patients before a diagnosis of mental manifestations to assist in the early identification of individuals at risk. Biological markers of alcoholism are separated into two groups: those biological variables that highlight with great confidence and validate the presence of a predisposition to alcoholism, also called trait markers, or those that highlight alcohol consumption, called markers of alcoholism (“status markers”). Biomarkers are the true “gold standard” for the diagnosis of alcoholism. They are valuable for tracking evolution and progress during biological and psychological therapy and for highlighting relapse. This review compiles the existing data from research on healthcare utilization, comorbidities, and alcohol consumption monitoring in patients before a diagnosis of mental manifestations to aid in the early identification of individuals at risk. This documentary study took place over three to four months by searching for terms on the Science Direct platform, PubMed, Web of Science, and Google Scholar such as alcoholism, alcohol use disorders, alcohol abuse, and biomarkers. Studies reporting on the development, characteristics, and utilization of blood biomarkers for alcohol consumption were included in the search. The initial search included a number of 11.019 articles that contained the keywords biomarkers and alcohol. Finally, a total of 50 research articles were considered. I am involved in clinical studies, meta-analyses, reviews, and case studies regarding alcohol consumption detection, as well as potential alcohol markers.
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饮酒的精神表现和生物标志物
本研究的目的是在诊断出精神症状之前,对患者的医疗保健使用情况、发病率和饮酒量进行监测,以帮助及早识别高危人群。酗酒的生物标志物分为两类:一类是非常有把握地强调和验证存在酗酒倾向的生物变量,也称为特质标志物;另一类是强调酒精消耗的生物变量,称为酗酒标志物("状态标志物")。生物标志物是诊断酗酒的真正 "金标准"。它们对于跟踪生物和心理治疗过程中的演变和进展,以及突出复发情况都很有价值。本综述汇编了现有的研究数据,这些数据涉及患者在被诊断出精神症状之前的医疗保健利用率、合并症和酒精消耗量监测,以帮助早期识别高危人群。这项文献研究历时三至四个月,通过在 Science Direct 平台、PubMed、Web of Science 和 Google Scholar 上搜索酗酒、酒精使用障碍、酒精滥用和生物标志物等术语来完成。报告酒精消费血液生物标志物的开发、特点和使用情况的研究也在搜索之列。初步搜索包括了 11.019 篇包含生物标志物和酒精关键词的文章。最后,共考虑了 50 篇研究文章。我参与了有关酒精消耗检测以及潜在酒精标志物的临床研究、荟萃分析、综述和案例研究。
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