Assessment of the Acute Toxicity of Chlorophyllin and Trolox for the Possibility of Studying Their Radioprotective Properties.

L. Romodin, O. Nikitenko, T. M. Bychkova, Yu. A. Zrilova, E. D. Rodionova, D. A. Bocharov
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Abstract

The acute toxicity of chlorophyllin and trolox upon intraperitoneal injection of their solutions was studied in male ICR (CD-1) mice. The LD50 of chlorophyllin was found to be 633±37.2 μg/g body weight, which is lower than the LD50 of established radioprotectors. Trolox is technically non-toxic under the conditions of our study. The results obtained highlight the need for a detailed study of the radioprotective properties of trolox and chlorophyllin.
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评估叶绿素和 Trolox 的急性毒性以研究其辐射防护特性的可能性。
研究了雄性 ICR(CD-1)小鼠腹腔注射叶绿素和特罗昔溶液后的急性毒性。研究发现,叶绿素的半数致死剂量为 633±37.2 微克/克体重,低于已确定的辐射防护剂的半数致死剂量。在我们的研究条件下,三氯氧烷在技术上是无毒的。研究结果表明,有必要对曲洛毒素和叶绿素的辐射防护特性进行详细研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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