Monitoring and Evaluation of Pharmaceutical Eco-Pollutants in Wastewater in Kazakhstan Cities

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-01 DOI:10.12911/22998993/189229

Symbat Tulegenova, Bolatbek Zhantokov, R. Beisenova, Zhadra A. Shingisbayeva, Asiya Dukenbayeva, Zhanar Rakhymzhan

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Abstract

Currently, the pharmaceutical industry is one of the most developing and dynamic sectors of the global economy. Existing methods of wastewater treatment do not always allow the complete removal of pharmacological preparations, which leads to the fact that these substances enter water resources and can have a negative impact on ecosystems and human health. Due to the increase in water pollution with pharmacological preparations, there is a need for more in-depth research in this area. Assessment of the level of contamination with pharmacological substances in the wastewater of megacities is an important aspect of environmental protection and public health. The purpose of this research work is to evaluate pharmacological pollutants in the wastewater of megacities. This study is aimed at identifying APIs (active pharmaceutical ingredients) that are most likely to have a negative impact on the envi - ronment in Kazakhstan. To analyze the content of Amoxicillin, Clarithromycin, Ofloxacin, Ciprofloxacin, Ateno - lol, Metoprolol, Propranolol, Paracetamol, Ibuprofen, Diclofenac, Cabramazepine and other medicinal substances, standards of these substances were added to the wastewater sample and analyzed by the HPLC-MS method. As a result of this research work, information was obtained on the current level of contamination with pharmacological substances in the wastewater of megacities and their impact on ecosystems and human health. The results of the study can be used to develop measures to reduce pollution and conserve water resources for future generations.

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监测和评估哈萨克斯坦城市废水中的药物生态污染物

目前，制药业是全球经济中最具发展活力的行业之一。现有的废水处理方法并不总能完全去除药物制剂，这导致这些物质进入水资源，对生态系统和人类健康造成负面影响。由于药物制剂造成的水污染日益严重，有必要在这一领域开展更深入的研究。评估特大城市废水中药剂物质的污染程度是环境保护和公共卫生的一个重要方面。这项研究工作的目的是评估特大城市废水中的药理污染物。本研究旨在确定最有可能对哈萨克斯坦环境产生负面影响的原料药（活性药物成分）。为了分析阿莫西林、克拉霉素、氧氟沙星、环丙沙星、阿替洛尔、美托洛尔、普萘洛尔、扑热息痛、布洛芬、双氯芬酸、卡马西平和其他药用物质的含量，在废水样品中加入了这些物质的标准品，并采用 HPLC-MS 方法进行分析。通过这项研究工作，我们获得了有关当前特大城市废水中药用物质污染程度及其对生态系统和人类健康影响的信息。研究结果可用于为子孙后代制定减少污染和保护水资源的措施。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.