A sustainable approach to microwave assisted synthesis of 2-(het)/arylquinazolin-4(3H)-ones via ionic liquid supported Cu(II) catalyst

Abstract

An efficient and sustainable approach for the microwave assisted synthesis of 2-(het)/arylquinazolin-4(3H)-ones from substituted 2-aminobenzamide and benzyl alcohols is introduced by using a reusable imidazolium based ionic liquid supported Cu(II) catalyst. This methodology exhibits high functional group tolerance and efficiently constructs desired products in good to excellent yields. Moreover, this method portrays operational simplicity, less reaction time, minimal cost and sustainable over the reported protocols. Furthermore, the catalyst can be recycled and reused up to 4 consecutive cycles with no significant loss of activity.