Development of a Neutron Activation Analysis Method for Studying the Elemental Composition of Atherosclerotic Plaques

IF 0.9 Q4 CHEMISTRY, INORGANIC & NUCLEAR Radiochemistry Pub Date : 2024-07-16 DOI:10.1134/s1066362224030081
E. A. Danilova, N. S. Osinskaya, B. I. Kurbanov, S. K. Khudoynazarov, S. H. Khusniddinova
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Abstract

Atherosclerosis is one of the most important problems of modern medicine. It involves changes in the structure and inner lining of the arteries. Studying chemical elements directly in vascular tissues allows understanding the mechanisms of evolvement of cardiovascular diseases, in particular, atherosclerosis. This study is aimed at developing the neutron activation technique for the analysis of atherosclerotic plaques formed at various stages of the atherosclerosis and studying their composition. The content of 13 elements in lipid, fibrous, ulcerated, and calcific plaques was determined using the developed method. It was established that upon evolving atherosclerosis, the content of a number of essential elements changes, the content of calcium, strontium, selenium, zinc and iron increases, and the bromine content decreases. Also, it was suggested that iron plays a role in the evolution of atherosclerotic vascular lesions.

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开发用于研究动脉粥样硬化斑块元素组成的中子活化分析方法
摘要 动脉粥样硬化是现代医学最重要的问题之一。它涉及动脉结构和内膜的变化。直接研究血管组织中的化学元素有助于了解心血管疾病,特别是动脉粥样硬化的演变机制。这项研究旨在开发中子活化技术,用于分析动脉粥样硬化不同阶段形成的动脉粥样硬化斑块,并研究其成分。使用开发的方法测定了脂质斑块、纤维斑块、溃疡斑块和钙化斑块中 13 种元素的含量。结果表明,在动脉粥样硬化演变过程中,一些必需元素的含量发生了变化,钙、锶、硒、锌和铁的含量增加,而溴的含量减少。此外,研究还表明,铁在动脉粥样硬化血管病变的演变过程中起着一定的作用。
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来源期刊
Radiochemistry
Radiochemistry CHEMISTRY, INORGANIC & NUCLEAR-
CiteScore
1.30
自引率
33.30%
发文量
51
期刊介绍: Radiochemistry  is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.
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