Directed Hydrothermal Synthesis of Aluminosilicates of Various Structural Types and Prospects for Their Use in Medicine

IF 1.8 3区 化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Russian Journal of Inorganic Chemistry Pub Date : 2024-07-17 DOI:10.1134/s0036023623603380
O. Yu. Golubeva, Yu. A. Alikina, E. Yu. Brazovskaya, N. Yu. Ul’yanova
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Abstract

The results of analysis and experimental studies of the possibilities of using synthetic aluminosilicates (montmorillonites, kaolinites, and zeolites) in medicine are presented. In particular, the following application fields are discussed: the field of enterosorption and hemosorption, the development of targeted drug delivery systems with prolonged and pH-controlled release of the active substance in various environments, as well as components of wound dressings. Montmorillonites, aluminosilicates of the kaolinite subgroup with different particle morphologies and zeolites of structural types Beta, Rho, and Y have been obtained under hydrothermal conditions and characterized by physicochemical methods. The results of studying the adsorption and desorption of model drugs (thiamine hydrochloride, and 5-fluorouracil) from porous aluminosilicate matrices of various chemical compositions in various media simulating body environments, adsorption of markers of endogenous intoxication (methylene blue), the ability of aluminosilicates to biodegrade in body environments, and studies of biological activity, in particular cytotoxicity and hemolytic activity of synthetic aluminosilicates, are presented. The results obtained show significant prospects for the use of synthetic aluminosilicates to obtain non-toxic, highly effective sorbents for medical use and drug carriers.

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各种结构类型铝硅酸盐的定向水热合成及其在医学中的应用前景
摘要 介绍了对合成铝硅酸盐(蒙脱石、高岭土和沸石)用于医药的可能性进行分析和实验研究的结果。特别讨论了以下应用领域:肠道吸附和血液吸附领域、开发可在各种环境中延长活性物质释放时间并控制 pH 值的靶向给药系统以及伤口敷料成分。我们在水热条件下获得了具有不同颗粒形态的蒙脱石、高岭石亚群的铝硅酸盐以及结构类型为 Beta、Rho 和 Y 的沸石,并通过物理化学方法对其进行了表征。研究结果包括:在各种模拟人体环境的介质中,不同化学成分的多孔铝硅酸盐基质对模型药物(盐酸硫胺素和 5-氟尿嘧啶)的吸附和解吸;对内源性中毒标记物(亚甲蓝)的吸附;铝硅酸盐在人体环境中的生物降解能力;以及对生物活性的研究,特别是合成铝硅酸盐的细胞毒性和溶血活性。研究结果表明,利用合成铝硅酸盐获得无毒、高效的医疗用吸附剂和药物载体具有广阔的前景。
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来源期刊
Russian Journal of Inorganic Chemistry
Russian Journal of Inorganic Chemistry 化学-无机化学与核化学
CiteScore
3.10
自引率
38.10%
发文量
237
审稿时长
3 months
期刊介绍: Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.
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