Fluoroestradiol PET-MRI imaging for detection of endometriosis lesions and symptom correlation.

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING American journal of nuclear medicine and molecular imaging Pub Date : 2024-06-15 eCollection Date: 2024-01-01 DOI:10.62347/JOQM7920
Jorge D Oldan, Yueh Z Lee, Kristen OIinger, Thad S Benefield, Erin T Carey, Noor D Abu-Alnadi, Steven L Young
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Abstract

Endometriosis is a common cause of infertility, pelvic pain, and dysmenorrhea and there are prior case reports of lesion detection using an 18F-fluoroestradiol (FES) tracer with positron emission tomography (PET). We aimed to further investigate the use of the FES tracer in the context of PET-magnetic resonance (PET-MR) imaging. We administered FES to 6 patients and then imaged them using a Siemens mMR PET-MR scanner. Each patient was taken to surgery within 30 days after imaging, and surgical visualization served as the gold-standard for diagnosis. PET did not prove to be as sensitive as MR (50% per-patient sensitivity versus 67% per-patient and 35% versus 48% per-lesion), and did not show any additional sites over and above MR. When MR was used to localize lesions on PET after imaging, there was insufficient evidence of an association between total tracer uptake and reported pain intensity (P=0.25). FES PET-MR offers no additional value to MR for endometriosis.

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用于检测子宫内膜异位症病灶和症状相关性的氟雌二醇 PET-MRI 成像。
子宫内膜异位症是导致不孕、盆腔疼痛和痛经的常见原因之一,之前有病例报告称使用 18F-氟雌二醇(FES)示踪剂和正电子发射断层扫描(PET)检测病灶。我们旨在进一步研究在 PET-MR 成像中使用 FES 示踪剂的情况。我们为 6 名患者注射了 FES,然后使用西门子 mMR PET-MR 扫描仪对他们进行了成像。每位患者都在成像后 30 天内接受了手术,手术可视化是诊断的金标准。事实证明,正电子发射计算机断层显像的灵敏度不如核磁共振(每位患者的灵敏度为 50%,而核磁共振为 67%;每个病灶的灵敏度为 35%,而核磁共振为 48%),而且在核磁共振的基础上没有显示任何额外的部位。在成像后使用 MR 在 PET 上定位病灶时,没有足够证据表明示踪剂摄取总量与报告的疼痛强度之间存在关联(P=0.25)。对子宫内膜异位症而言,FES PET-MR 没有 MR 的额外价值。
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来源期刊
American journal of nuclear medicine and molecular imaging
American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
自引率
4.00%
发文量
4
期刊介绍: The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.
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