Mortality case due to minimal bentazone intoxication.

IF 1.9 Q2 EMERGENCY MEDICINE Clinical and Experimental Emergency Medicine Pub Date : 2024-07-19 DOI:10.15441/ceem.24.217
Yumin Jeon, Sejoong Ahn, Jong-Hak Park, Hanjin Cho, Sungwoo Moon, Sukyo Lee
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Abstract

Bentazone is a widely used herbicide and is considered a moderate hazard. Fatalities are rarely reported, with reports of deaths occurring in doses of 200 ml or more. In some literature, it is accompanied by generalized rigidity. Malignant hyperthermia (MH) is a pharmacogenetic diseases that presents a hypermetabolic response to anesthetic gases or depolarizing muscle relaxant due to calcium channel dysfunction. The classic symptom of MH include hyperthermia and muscle rigidity. In this article, we report a case of a 65-year-old man who died 4 hours after presenting to the emergency department after taking approximately 75 ml of Basagran M60 (bentazone 33.6%, 25.2 g). This is the smallest dose (364 mg/kg) reported in a fatal case to date. Electrocardiogram changes, including QRS widening and QT prolongation, were present, and hypocalcemia was confirmed. We propose the possibility that bentazone intoxication causes patient deterioration by a mechanism similar to malignant hyperthermia.

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因轻度苯达松中毒而死亡的病例。
本草酮是一种广泛使用的除草剂,被认为具有中等危害。很少有致死的报道,但有报道称剂量达到或超过 200 毫升时会导致死亡。在一些文献中,它还伴有全身僵硬。恶性高热(MH)是一种药物遗传性疾病,由于钙通道功能障碍,患者会对麻醉气体或去极化肌肉松弛剂产生高代谢反应。MH 的典型症状包括高热和肌肉僵硬。在本文中,我们报告了一例 65 岁男子的病例,他在服用了约 75 毫升 Basagran M60(苯达宗 33.6%,25.2 克)后,在急诊科就诊 4 小时后死亡。这是迄今为止在死亡病例中报告的最小剂量(364 毫克/千克)。出现了心电图变化,包括 QRS 增宽和 QT 间期延长,并确诊为低钙血症。我们认为,苯达松中毒导致患者病情恶化的机制可能与恶性高热症类似。
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来源期刊
CiteScore
2.80
自引率
10.50%
发文量
59
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