Metastatic renal cell carcinoma with occult primary: a multicenter prospective cohort

IF 6.8 1区医学 Q1 ONCOLOGY NPJ Precision Oncology Pub Date : 2024-07-18 DOI:10.1038/s41698-024-00648-0

Nicolas Jacquin, Ronan Flippot, Julien Masliah-Planchon, Guillaume Grisay, Riwan Brillet, Célia Dupain, Maud Kamal, Isabelle Guillou, Nadège Gruel, Nicolas Servant, Pierre Gestraud, Jennifer Wong, Vincent Cockenpot, Andreia Goncalves, Janick Selves, Hélène Blons, Etienne Rouleau, Olivier Delattre, Claire Gervais, Christophe Le Tourneau, Ivan Bièche, Yves Allory, Laurence Albigès, Sarah Watson

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Abstract

Metastatic carcinoma of presumed renal origin (rCUP) has recently emerged as a new entity within the heterogeneous entity of Cancers of Unknown Primary (CUP) but their biological features and optimal therapeutic management remain unknown. We report the molecular characteristics and clinical outcome of a series of 25 rCUP prospectively identified within the French National Multidisciplinary Tumor Board for CUP. This cohort strongly suggests that rCUP share similarities with common RCC subtypes and benefit from renal-tailored systemic treatment. This study highlights the importance of integrating clinical and molecular data for optimal diagnosis and management of CUP.

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隐匿原发的转移性肾细胞癌：多中心前瞻性队列。

最近，推测为肾源性的转移癌（rCUP）作为不明原发癌（CUP）异质性实体中的一个新实体出现，但其生物学特征和最佳治疗方法仍不为人知。我们报告了法国国家 CUP 多学科肿瘤委员会前瞻性发现的 25 例 rCUP 的分子特征和临床结果。该队列有力地表明，rCUP 与常见的 RCC 亚型有相似之处，并能从肾脏定制的系统治疗中获益。这项研究强调了整合临床和分子数据以优化 CUP 诊断和管理的重要性。

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来源期刊

NPJ Precision Oncology ONCOLOGY-

CiteScore

9.90

自引率

1.30%

发文量

审稿时长

18 weeks

期刊介绍： Online-only and open access, npj Precision Oncology is an international, peer-reviewed journal dedicated to showcasing cutting-edge scientific research in all facets of precision oncology, spanning from fundamental science to translational applications and clinical medicine.