Evaluation of wakefulness electroencephalogram in OSA patients.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY Sleep and Breathing Pub Date : 2024-10-01 Epub Date: 2024-07-19 DOI:10.1007/s11325-024-03116-y

Isabel Ferreira, Patrícia Guerra, Nuno Pinto, Daniel Alfaiate, Alexandre Pereira

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Abstract

Objective: Obstructive sleep apnea (OSA) has been associated with an elevated cardiovascular risk, increased daytime sleepiness, cognitive decline, and slower electroencephalographic activity (EEG). This study assesses EEG patterns during wakefulness in OSA patients compared to those without sleep-disordered breathing.

Materials and methods: This retrospective study analyzed 30 OSA patients with an Apnea/Hypopnea Index (AHI) of 15 or higher, as well as 29 individuals without sleep-disordered breathing (AHI of 5 or lower) who underwent hospital polysomnography and met all inclusion criteria. Sociodemographic and EEG data were obtained from the sleep laboratory database. Blinded EEG analysis was conducted by two observers, assessing activity in the frontal, central, and occipital regions.

Results: No significant differences were observed in EEG activity between OSA and non-OSA patients. However, a weak correlation was found between decreased C3 EEG frequency and higher AHI (p = 0.033), as well as increased total sleep time and higher O2 EEG frequency (p = 0.038). Lower amplitudes in C3 (p = 0.043) and O1 (p = 0.031) were correlated with reduced average oxygen saturation.

Conclusion: Our findings suggest that OSA-related hypoxemia may impact neuronal activity, highlighting the need to address this sleep-disordered breathing in order to potentially prevent the cognitive decline observed in OSA patients.

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评估 OSA 患者的清醒脑电图。

目的：阻塞性睡眠呼吸暂停（OSA阻塞性睡眠呼吸暂停（OSA）与心血管风险升高、白天嗜睡增加、认知能力下降和脑电活动（EEG）减慢有关。本研究评估了 OSA 患者清醒时的脑电图模式，并与无睡眠呼吸障碍的患者进行了比较：这项回顾性研究分析了 30 名呼吸暂停/高通气指数（AHI）为 15 或更高的 OSA 患者，以及 29 名无睡眠呼吸障碍（AHI 为 5 或更低）的患者，他们都在医院接受了多导睡眠图检查，并符合所有纳入标准。社会人口学和脑电图数据均来自睡眠实验室数据库。由两名观察员进行盲法脑电图分析，评估额叶、中央和枕叶区域的活动：结果：OSA 患者和非 OSA 患者的脑电图活动无明显差异。然而，在 C3 脑电图频率降低和 AHI 增加（p = 0.033）以及总睡眠时间增加和 O2 脑电图频率增加（p = 0.038）之间发现了微弱的相关性。C3（p = 0.043）和O1（p = 0.031）振幅较低与平均血氧饱和度降低相关：我们的研究结果表明，与 OSA 相关的低氧血症可能会影响神经元的活动，因此需要解决这种睡眠呼吸紊乱问题，以防止 OSA 患者的认知能力下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep and Breathing 医学-呼吸系统

CiteScore

5.20

自引率

4.00%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.