Impact of serious adverse drug reactions on the quality of life of patients on highly active antiretroviral therapy in Maiduguri, northeast Nigeria: a four-year retrospective study.

IF 1.2 4区 医学 Q4 HEALTH POLICY & SERVICES Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-08-01 Epub Date: 2024-07-18 DOI:10.1080/09540121.2024.2365857
Peter U Bassi, W Gashau
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Abstract

ABSTRACTSerious adverse drug reactions (sADRs) have a serious impact on the progress being made in providing antiretroviral therapy. The presence of HIV/AIDS and its complications associated with sADRs, has a negative effect on the quality of life (QoL) of people living with HIV/AIDS (PLWHA). This was a descriptive retrospective cohort study of 400 adult HIV patients in which the QoL of PLWHA with sADRs was compared to patients that did not experience ADR who had been on antiretroviral therapy (ART) was followed up for 48 months using the WHOQOL-HIV BREF to measure QoL. Out of 400 patients, 373 (93.25%) respondents completed the study with an overall mean age was 40.8 years (SD ± 8.64). One hundred and ninety-nine patients (53.4%) reported to have experiencing sADR. The response consistently showed significantly higher mean scores in the QoL of patients who had no ADRs in the psychological, social and environments state of health domains compared to those who had ADRs with mean scores (P = 0.000, 0.037 and 0.028), respectively. This study revealed significantly higher scores in patients who had no ADRs compared to those who had ADRs. Low QoL due to serious ADR may add additional burden to HIV disease and complications, and the related discrimination often faced by PLWHA. This study would help clinicians pay serious attention to identifying and promptly managing ADR.

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严重药物不良反应对尼日利亚东北部迈杜古里高度活跃抗逆转录病毒疗法患者生活质量的影响:一项为期四年的回顾性研究。
摘要严重药物不良反应(sADRs)严重影响了抗逆转录病毒疗法的进展。艾滋病毒/艾滋病及其与药物不良反应相关的并发症对艾滋病毒/艾滋病感染者(PLWHA)的生活质量(QoL)产生了负面影响。这是一项对 400 名成年艾滋病患者进行的描述性回顾性队列研究,其中使用 WHOQOL-HIV BREF 对接受抗逆转录病毒疗法(ART)的患者的 QoL 进行了 48 个月的随访,并将出现 sADRs 的 PLWHA 与未出现 ADRs 的患者的 QoL 进行了比较。在 400 名患者中,有 373 名(93.25%)受访者完成了研究,总平均年龄为 40.8 岁(SD ± 8.64)。199 名患者(53.4%)表示曾经历过 sADR。研究结果一致显示,在心理、社会和环境健康状况方面,未发生 ADR 的患者的 QoL 平均得分明显高于发生 ADR 的患者,平均得分分别为(P = 0.000、0.037 和 0.028)。本研究显示,与出现 ADR 的患者相比,未出现 ADR 的患者得分明显较高。因严重 ADR 而导致的低 QoL 可能会增加 HIV 疾病和并发症的额外负担,以及 PLWHA 经常面临的相关歧视。这项研究将有助于临床医生重视识别和及时处理 ADR。
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来源期刊
CiteScore
3.50
自引率
0.00%
发文量
172
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