Contemporary Diagnostic Work-Up for Male Infertility: Emphasizing Comprehensive Baseline Assessment.

IF 4 3区 医学 Q1 ANDROLOGY World Journal of Mens Health Pub Date : 2024-06-19 DOI:10.5534/wjmh.240069
Edoardo Pozzi, Federico Belladelli, Christian Corsini, Luca Boeri, Paolo Capogrosso, Giuseppe Fallara, Luigi Candela, Alessandro Bertini, Francesco Cattafi, Massimiliano Raffo, Walter Cazzaniga, Eugenio Ventimiglia, Alessia d'Arma, Massimo Alfano, Rayan Matloob, Enrico Papaleo, Massimo Candiani, Francesco Montorsi, Andrea Salonia
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Abstract

Infertility is a prevalent issue affecting many couples during their reproductive years, with a significant number facing challenges in conceiving despite regular unprotected intercourse. Male factor infertility (MFI) contributes significantly to these cases, with a significant proportion of men lacking an identifiable etiology. As such, a thorough assessment of MFI has become increasingly vital for personalized management. This position paper from the Andrology team at IRCCS Ospedale San Raffaele emphasizes a comprehensive and individualized approach to MFI work-up, addressing the evolving challenges encountered in clinical practice. Our approach involves a thorough diagnostic work-up to identify the underlying causes of MFI, integrating insights from extensive literature review and our proprietary data. Our data demonstrates that an extensive diagnostic assessment allows us to identify at least one underlying cause of MFI in most infertile men. However, challenges persist in diagnosing less severe phenotypes with unclear etiology. We discuss the importance of individualized MFI work-up and its implications for developing rational therapeutic protocols. Lastly, this paper highlights the necessity for a personalized diagnostic assessment, addressing the daily clinical challenges and emphasizing tailored approaches to try to improve outcomes among couples seeking first medical help for infertility.

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男性不育症的当代诊断工作:强调综合基线评估。
不孕不育是影响许多育龄夫妇的一个普遍问题,尽管经常进行无保护的性交,但仍有相当多的夫妇面临怀孕的挑战。男性因素不育(MFI)在这些病例中占很大比例,其中相当一部分男性缺乏可确定的病因。因此,对男性因素不育进行全面评估对于个性化管理越来越重要。这份立场文件由 IRCCS Ospedale San Raffaele 的 Andrology 团队撰写,强调了一种全面、个性化的 MFI 检查方法,以应对临床实践中遇到的不断变化的挑战。我们的方法包括全面的诊断检查,以确定 MFI 的根本原因,并将广泛的文献综述和我们的专有数据进行整合。我们的数据表明,通过广泛的诊断评估,我们可以在大多数不育男性中找出至少一种导致 MFI 的根本原因。然而,在诊断病因不明确的较轻表型时仍存在挑战。我们讨论了个体化 MFI 检查的重要性及其对制定合理治疗方案的影响。最后,本文强调了进行个性化诊断评估的必要性,以应对日常临床挑战并强调量身定制的方法,以努力改善因不孕症而首次寻求医疗帮助的夫妇的治疗效果。
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来源期刊
World Journal of Mens Health
World Journal of Mens Health Medicine-Psychiatry and Mental Health
CiteScore
7.60
自引率
2.10%
发文量
92
审稿时长
6 weeks
期刊最新文献
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