Investigation of the pathophysiology of epiretinal membrane foveoschisis: An analysis of longitudinal changes in visual functions, retinal structures, and retinal traction force.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-07-18 DOI:10.1097/IAE.0000000000004217

Ryo Matoba, Yuki Kanzaki, Tetsuro Morita, Yuki Masuda, Shuhei Kimura, Mio M Hosokawa, Yusuke Shiode, Yuki Morizane

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Abstract

Purpose: To analyze the pathophysiology of epiretinal membrane foveoschisis (ERM-FS) by evaluating the longitudinal changes in visual function and several optical coherence tomography (OCT) parameters.

Methods: The medical records of 33 consecutive patients (35 eyes) with untreated ERM-FS were retrospectively reviewed. Best-corrected visual acuity (BCVA), M-CHARTS score, and OCT parameters including ERM area, maximum depth of retinal folds (MDRF), FS area, and FS circularity were evaluated.

Results: A wide range of FS area changes was observed at the final follow-up visit (59.68-240.45% of the baseline FS area). In the FS enlargement group, BCVA and mean M-CHARTS scores significantly worsened and MDRF significantly increased over time, whereas in the FS non-enlargement group, no significant change was observed in BCVA, mean M-CHARTS scores, or MDRF during the follow-up period. Multivariate logistic regression analyses revealed that MDRF (odds ratio: 1.05, 95% confidence interval: 1.00-1.10, P = 0.048) and FS circularity (odds ratio: 0.91, 95% confidence interval: 0.83-1.00, P = 0.043) were significantly associated with FS enlargement.

Conclusion: ERM-FS encompasses diverse pathophysiologies. Since visual functions do not worsen in some cases, monitoring the changes in visual functions and retinal morphology over time is recommended to determine surgical indications.

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研究视网膜外膜眼窝裂孔的病理生理学：视觉功能、视网膜结构和视网膜牵引力的纵向变化分析。

目的：通过评估视觉功能的纵向变化和几项光学相干断层扫描（OCT）参数，分析视网膜外膜眼窝畸形（ERM-FS）的病理生理学：方法：回顾性审查了33名未经治疗的ERM-FS患者（35只眼）的病历。评估了最佳矫正视力（BCVA）、M-CHARTS评分以及包括ERM面积、视网膜皱褶最大深度（MDRF）、FS面积和FS圆度在内的OCT参数：最终随访观察到的 FS 面积变化范围较大（基线 FS 面积的 59.68%-240.45%）。随着时间的推移，FS扩大组的BCVA和M-CHARTS平均评分显著恶化，MDRF显著增加，而FS未扩大组的BCVA、M-CHARTS平均评分或MDRF在随访期间无显著变化。多变量逻辑回归分析显示，MDRF（几率比：1.05，95% 置信区间：1.00-1.10，P = 0.048）和FS圆度（几率比：0.91，95% 置信区间：0.83-1.00，P = 0.043）与FS扩大显著相关：结论：ERM-FS包含多种病理生理学。结论：ERM-FS 包含多种病理生理机制，由于部分病例视功能不会恶化，因此建议监测视功能和视网膜形态随时间的变化，以确定手术适应症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.

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