Blueberries in focus: Exploring the phytochemical potentials and therapeutic applications

IF 4.8 Q1 AGRICULTURE, MULTIDISCIPLINARY Journal of Agriculture and Food Research Pub Date : 2024-07-19 DOI:10.1016/j.jafr.2024.101300
Sumel Ashique , Tuhin Mukherjee , Satyajit Mohanty , Ashish Garg , Neeraj Mishra , Monika Kaushik , Mithun Bhowmick , Bornika Chattaraj , Sourav Mohanto , Shriyansh Srivastava , Farzad Taghizadeh-Hesary
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Abstract

Blueberries, which belong to the Vaccinium spp. Genus, have attracted considerable interest because of their abundant phytochemical composition and potential for medicinal uses. The present study examines the many phytochemicals found in blueberries, such as anthocyanins, flavonoids, phenolic acids, and stilbenes, as well as their biological activities contributing to the health benefits of blueberries. Anthocyanins, the primary pigments that give blueberries their unique color, are renowned for their powerful antioxidant capabilities. These substances counteract oxidative stress by neutralizing free radicals, decreasing the likelihood of developing chronic illnesses such as cardiovascular disease, cancer, and neurological disorders. Furthermore, the presence of flavonoids and phenolic acids in blueberries contributes to their ability to reduce inflammation, prevent cancer, and protect the brain, improving their potential for therapeutic use. This study delves into the bioavailability and metabolism of these phytochemicals, specifically examining the impact of factors like food composition, gut microorganisms, and individual metabolic variations on their effectiveness. Both clinical and preclinical studies provide strong evidence for the beneficial effects of blueberries on multiple health factors, such as enhanced cognitive function, lowered blood pressure, and improved insulin sensitivity. These findings suggest that blueberries may play a significant role in managing conditions like Alzheimer's disease, hypertension, and diabetes. Moreover, this study examines the synergistic impacts of blueberry phytochemicals, suggesting that the health advantages of blueberries arise not alone from individual substances but also from their collective interactions. Proposed future study areas include the advancement of functional foods and nutraceuticals derived from blueberries, as well as the need for standardized clinical studies to determine appropriate dose guidelines and ensure long-term safety. Overall, the significant variety of phytochemicals in blueberries and their potential for therapeutic use make them a promising functional food. Further research into these substances' mechanisms of action and therapeutic uses will clarify their function in enhancing human health and avoiding illness.

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聚焦蓝莓:探索植物化学潜力和治疗应用
蓝莓属于越橘属,因其丰富的植物化学成分和药用潜力而备受关注。本研究探讨了蓝莓中发现的多种植物化学物质,如花青素、类黄酮、酚酸和二苯乙烯,以及它们对蓝莓健康益处的生物活性。花青素是赋予蓝莓独特颜色的主要色素,因其强大的抗氧化能力而闻名。这些物质通过中和自由基来抵消氧化压力,降低患心血管疾病、癌症和神经系统疾病等慢性疾病的可能性。此外,蓝莓中含有的类黄酮和酚酸也有助于减少炎症、预防癌症和保护大脑,从而提高其治疗用途的潜力。本研究深入探讨了这些植物化学物质的生物利用率和新陈代谢,特别是研究了食物成分、肠道微生物和个体新陈代谢变化等因素对其有效性的影响。临床和临床前研究都有力地证明了蓝莓对多种健康因素的有益影响,如增强认知功能、降低血压和改善胰岛素敏感性。这些研究结果表明,蓝莓可在控制阿尔茨海默病、高血压和糖尿病等疾病方面发挥重要作用。此外,本研究还探讨了蓝莓植物化学物质的协同作用,表明蓝莓的健康优势不仅来自于单个物质,还来自于它们的集体相互作用。建议的未来研究领域包括开发蓝莓衍生的功能食品和营养保健品,以及开展标准化临床研究以确定适当剂量指南并确保长期安全性的必要性。总之,蓝莓中种类繁多的植物化学物质及其潜在的治疗用途使其成为一种前景广阔的功能性食品。对这些物质的作用机制和治疗用途的进一步研究将明确它们在增进人类健康和避免疾病方面的功能。
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来源期刊
CiteScore
5.40
自引率
2.60%
发文量
193
审稿时长
69 days
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