1248-P: Association of Oxidative Stress Markers with Incident Hyperglycemia in Gestational Diabetes Mellitus—Impact of a Diabetes Prevention Program

IF 6.2 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes Pub Date : 2024-07-19 DOI:10.2337/db24-1248-p

MONICA L. RUIZ, RITA A. GOMEZ-DIAZ, ADRIANA LETICIA VALDEZ GONZALEZ, SELENE ÁNGELES MEJÍA, MARGARITA DIAZ-FLORES, RICARDO C. SALDAÑA ESPINOZA, MARY F. DÍAZ, LUZ ANGELICA RAMIREZ GARCIA, NIELS H. WACHER

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Abstract

Introduction & Objective: Gestational Diabetes (GDM) poses risk for developing type 2 diabetes (T2D). The role of oxidative stress in GDM and its association with incident diabetes remains unclear. This study aimed to assess the link between oxidative stress markers and incident hyperglycemia in women with and without GDM. Methods: Prospective cohort. Pregnant women with GDM (n=201) or without GDM (n=50) undergoing cesarean section participated in an 18-month postpartum prevention program. The program emphasized healthy practices, physical activity, and psychosocial support. Oxidative stress markers [malondialdehyde (MDA), reduced glutathione (GSH), antioxidant capacity (DPPH), carbonylated proteins], and adiponectin were measured at the end of pregnancy and at 18 months later. A control group (CG) (n=57) received standard care. Multiple linear regression identified intervention-related differences. Results: Baseline GDM women exhibited elevated oxidative stress markers and adiponectin compared to non-GDM counterparts. Antioxidant capacity was lower in GDM (40 vs. 67.8%, p=<0.001). Post-intervention, GDM cases showed a greater reduction in MDA and adiponectin (-37.55 vs-34.08 nmol, p=0.021; -751.54 vs-210.31 pg/mL, p<0.001 respectively) and antioxidant capacity increased (in both groups: 1.0 - 0.28%, vs CG -7.23 p=0.009). At follow-up, 6% progressed to T2D, and 37.3% to prediabetes. Basal malondialdehyde concentrations, pregestational BMI, and HbA1c positively correlated with incident hyperglycemia. Conversely, the change in carbonylated proteins concentrations inversely correlated with incident hyperglycemia. Conclusion: Oxidative markers are associated with T2D risk in GDM. The diabetes prevention program effectively reduced malondialdehyde and adiponectin levels. These findings highlight the role of oxidative stress in GDM prevention strategies. Disclosure M.L. Ruiz: None. R.A. Gomez-Diaz: None. A. Valdez Gonzalez: None. S. Ángeles Mejía: None. M. Diaz-Flores: None. R.C. Saldaña Espinoza: None. M.F. Díaz: None. L. Ramirez Garcia: None. N.H. Wacher: None. Funding Fundación Gonzalo Río Arronte, Institution of Private Assistance (S.0634), and the Coordinación de Investigación en Salud (R2022-785-057)

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1248-P：氧化应激标记物与妊娠期糖尿病高血糖的关系--糖尿病预防计划的影响

引言& 目的：妊娠期糖尿病（GDM）具有罹患 2 型糖尿病（T2D）的风险。氧化应激在 GDM 中的作用及其与糖尿病发病的关系仍不清楚。本研究旨在评估妊娠期糖尿病妇女和非妊娠期糖尿病妇女中氧化应激标记物与高血糖之间的联系。方法：前瞻性队列研究：前瞻性队列研究。接受剖宫产手术的 GDM 孕妇（人数=201）或未接受剖宫产手术的 GDM 孕妇（人数=50）参加了为期 18 个月的产后预防计划。该计划强调健康的生活方式、体育锻炼和社会心理支持。在妊娠结束时和 18 个月后，对氧化应激指标[丙二醛 (MDA)、还原型谷胱甘肽 (GSH)、抗氧化能力 (DPPH)、羰基化蛋白质]和脂肪连蛋白进行了测量。对照组（CG）（n=57）接受标准护理。多元线性回归确定了与干预相关的差异。结果显示与非 GDM 妇女相比，基线 GDM 妇女的氧化应激标记物和脂肪连接蛋白均升高。GDM 的抗氧化能力较低（40% 对 67.8%，p=<0.001）。干预后，GDM 病例的 MDA 和脂联素下降幅度更大（分别为 -37.55 vs-34.08 nmol，p=0.021；-751.54 vs-210.31 pg/mL，p<0.001），抗氧化能力提高（两组均为：1.0 - 0.28%，vs CG -7.23，p=0.009）。在随访中，6% 的人发展为 T2D，37.3% 的人发展为糖尿病前期。基础丙二醛浓度、孕前体重指数和 HbA1c 与高血糖事件呈正相关。相反，羰基化蛋白质浓度的变化与高血糖事件成反比。结论氧化标志物与 GDM 的 T2D 风险有关。糖尿病预防计划有效降低了丙二醛和脂肪连蛋白的水平。这些发现强调了氧化应激在 GDM 预防策略中的作用。披露 M.L. Ruiz：无。R.A. Gomez-Diaz：无。A. Valdez Gonzalez：无：无。S. Ángeles Mejía：S. Ángeles Mejía: None.M. Diaz-Flores：M. Diaz-Flores: None.R.C. Saldaña Espinoza: None.M.F. Díaz：L. Ramirez Garcia: None.L. Ramirez Garcia: None.N.H. Wacher：无。资助贡萨洛-里奥-阿隆特基金会、私人援助机构（S.0634）和健康研究协调机构（R2022-785-057）。

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来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.