The role of mesenchymal stem cells in the treatment and pathogenesis of psoriasis

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine Pub Date : 2024-07-20 DOI:10.1016/j.cyto.2024.156699

Yan-kun Chen , Asma’a H. Mohamed , Ahad Amer Alsaiari , Dmitry Olegovich Bokov , Ayyub Ali Patel , Waleed Al Abdulmonem , Alaa Shafie , Amal Adnan Ashour , Mohammad Azhar Kamal , Fuzail Ahmad , Irshad Ahmad

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Abstract

Psoriasis, a prevalent inflammatory skin condition impacting millions globally, continues to pose treatment challenges, despite the availability of multiple therapies. This underscores the demand for innovative treatments. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option due to their capacity to modulate the immune system and facilitate tissue healing. Recent research indicates that MSCs don’t just work through direct cell-to-cell interactions but also release extracellular vesicles (EVs), containing various bioactive substances like proteins, lipids, and nucleic acids. This article explores our current knowledge of psoriasis’s origins and the potential utilization of MSCs and their EVs, particularly exosomes, in managing the condition. Additionally, we delve into how MSCs and EVs function in therapy, including their roles in regulating immune responses and promoting tissue repair. Lastly, we discuss the obstacles and opportunities associated with translating MSC-based treatments for psoriasis into clinical practice.

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间充质干细胞在银屑病治疗和发病机制中的作用

牛皮癣是一种普遍存在的炎症性皮肤病，影响着全球数百万人，尽管已有多种疗法，但仍给治疗带来挑战。这凸显了对创新疗法的需求。间充质干细胞（MSCs）具有调节免疫系统和促进组织愈合的能力，已成为一种很有前景的治疗方法。最新研究表明，间充质干细胞不仅通过细胞间的直接相互作用发挥作用，还能释放细胞外囊泡（EVs），其中含有各种生物活性物质，如蛋白质、脂类和核酸。本文探讨了我们目前对牛皮癣起源的认识，以及间充质干细胞及其EVs（尤其是外泌体）在治疗牛皮癣方面的潜在用途。此外，我们还将深入探讨间叶干细胞和EVs在治疗中的作用，包括它们在调节免疫反应和促进组织修复方面的作用。最后，我们讨论了将基于间充质干细胞的银屑病治疗方法转化为临床实践的相关障碍和机遇。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.