Consecutive assessment of recovery after peripheral nerve injury of the sciatic nerve within the same rat using PET/MRI.

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Acta radiologica Pub Date : 2024-09-01 Epub Date: 2024-07-21 DOI:10.1177/02841851241265698
Jung Woo Nam, Dawei Song, Hyung Jun Kim
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Abstract

Background: Positron emission tomography (PET) has been reported as effective in diagnosing peripheral nerve injury (PNI). However, there is a lack of studies evaluating different degrees of PNI using PET within the same individual to reduce errors due to interindividual differences.

Purpose: To evaluate the recovery process in the same rat after sciatic nerve injury using PET/magnetic resonance imaging (MRI).

Material and methods: Crushing nerve injuries were induced in the left sciatic nerves of six male rats, preserving the right ones. The degree of nerve damage was measured at one, two, three, four, and five weeks postoperatively using three assessment methods: paw withdrawal threshold test (RevWT); PET (SUVR); and MRI (MRSIR). All the representing values of each method are presented as ratio values of the right and left sides in each rat.

Results: Significant gradual recovery of all rats was observed over time in all the methods. No significant differences in RevWT and MRSIR were observed between before and more than four weeks after injury, whereas a significant difference in SUVR was still observed between before and five weeks after injury (P = 0.0007). The parameters of all methods decreased significantly over time (P = 0.000, all), and the explanatory power was significant in RevWT, SUVR, and MRSIR.

Conclusion: PET and MRI could be valuable non-invasive techniques for diagnosing neuropathic pain resulting from PNI. PET/MRI would be expected to be a more accurate and informative diagnostic tool for PNI than MRI alone.

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利用 PET/MRI 对同一只大鼠坐骨神经周围神经损伤后的恢复情况进行连续评估。
背景:据报道,正电子发射断层扫描(PET)可有效诊断周围神经损伤(PNI)。目的:使用 PET/磁共振成像(MRI)评估同一只大鼠坐骨神经损伤后的恢复过程:材料:对六只雄性大鼠的左侧坐骨神经造成挤压性神经损伤,保留右侧神经。在术后一周、两周、三周、四周和五周,使用三种评估方法测量神经损伤程度:爪抽出阈值测试(RevWT)、正电子发射计算机断层显像(SUVR)和核磁共振成像(MRSIR)。每种方法的所有代表值均以每只大鼠左右两侧的比率值表示:结果:在所有方法中都观察到所有大鼠随着时间的推移明显逐渐恢复。RevWT 和 MRSIR 在受伤前和受伤后四周以上没有观察到明显差异,而 SUVR 在受伤前和受伤后五周仍有明显差异(P = 0.0007)。随着时间的推移,所有方法的参数都明显下降(P = 0.000,全部),RevWT、SUVR 和 MRSIR 的解释力显著增强:结论:PET 和 MRI 是诊断 PNI 引起的神经病理性疼痛的重要非侵入性技术。PET/MRI有望成为比单独 MRI 更准确、信息更丰富的 PNI 诊断工具。
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来源期刊
Acta radiologica
Acta radiologica 医学-核医学
CiteScore
2.70
自引率
0.00%
发文量
170
审稿时长
3-8 weeks
期刊介绍: Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.
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