Association Between Pentoxifylline Use and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease: A Multi-Institutional Cohort Study.

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomedical Journal Pub Date : 2024-07-19 DOI:10.1016/j.bj.2024.100771

Tzu-Yi Lin, Eugene Yu-Chuan Kang, Nan-Kai Wang, Je-Ho Kang, Kuan-Jen Chen, Wei-Chi Wu, Chi-Chun Lai, Yih-Shiou Hwang

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Abstract

Background: Pentoxifylline is administrated to improve the hemodynamics of patients with chronic kidney disease (CKD). Despite the improvement of capillary blood flow velocity in retina after pentoxifylline use, no evidence has been provided to prove the protective effect for diabetic retinopathy (DR). Therefore, this study aimed to assess the risk of DR in pentoxifylline users with CKD and diabetes mellitus (DM).

Material and methods: In this retrospective cohort study, Chang Gung Research Database, which includes the data of patients with CKD and DM from 2003 to 2019, was used. Each calendar year was divided into 4 data units with 3 months each for every patient and every year during the follow-up. The ocular outcomes were new-onset DR, DR-related complications, and vitreoretinal interventions.

Results: Total 56,439 patients without preexisting DR and 5,039 patients with preexisting DR were included in this study. Exposure to pentoxifylline was associated with elevated risk of new-onset DR (adjusted hazard ratio = 1.24, 95% confidence interval = 1.13-1.36) in patients without preexisting DR. Additionally, exposure to pentoxifylline was associated with elevated risk of DR-related complications and vitreoretinal interventions in patients with or without preexisting DR.

Conclusions: Exposure to pentoxifylline is associated with elevated risk of DR, regardless of whether patients have preexisting DR.

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2 型糖尿病合并慢性肾脏病患者使用五氧嘧啶与糖尿病视网膜病变之间的关系：一项多机构队列研究。

背景：使用五氧去氧肾上腺素可改善慢性肾脏病（CKD）患者的血液动力学。尽管使用五氧去氧肾上腺素后视网膜毛细血管血流速度有所改善，但尚无证据证明其对糖尿病视网膜病变（DR）有保护作用。因此，本研究旨在评估患有慢性肾脏病和糖尿病（DM）的戊唑醇使用者发生 DR 的风险：在这项回顾性队列研究中，使用了长庚研究数据库，其中包括 2003 年至 2019 年期间 CKD 和 DM 患者的数据。在随访期间，每个日历年分为 4 个数据单元，每个单元为每个患者和每年 3 个月。眼部结果包括新发 DR、DR 相关并发症和玻璃体视网膜干预：本研究共纳入了 56439 名未患 DR 的患者和 5039 名已患 DR 的患者。在无原有 DR 的患者中，接触戊氧地塞米松与新发 DR 风险升高有关（调整后危险比 = 1.24，95% 置信区间 = 1.13-1.36）。此外，无论是否已存在DR，暴露于戊氧肾上腺素均与DR相关并发症和玻璃体视网膜干预风险升高有关：结论：无论患者是否患有先天性DR，接触戊乙福林都与DR风险升高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Journal Medicine-General Medicine

CiteScore

11.60

自引率

1.80%

发文量

128

审稿时长

42 days

期刊介绍： Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs. Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology. A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.