Which outcomes are key to the pre-intervention assessment profile of a child with developmental coordination disorder? A systematic review and meta-analysis.

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomedical Journal Pub Date : 2024-07-18 DOI:10.1016/j.bj.2024.100768

Bouwien Smits-Engelsman, Marisja Denysschen, Jessica Lust, Dané Coetzee, Ludvik Valtr, Marina Schoemaker, Evi Verbecque

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Abstract

Background: Purpose of this study was to determine what key aspects of function should be incorporated to make up a pre-intervention assessment profile of a child with Developmental Coordination Disorder (DCD); more specifically, what aspects of functioning are implicated in DCD and what is their relative impact?

Methods: A systematic review and meta-analysis were conducted, for which Pubmed, Web of Science, Scopus and Proquest were searched (last update: April 2023, PROSPERO: CRD42023461619). Case-control studies were included to determine point estimates for performances on field-based tests in different domains of functioning. Risk of bias was assessed, and level of evidence estimated. Random-effect meta-analyses were performed to calculate the pooled standardized mean differences for domains of functioning and subgrouping was done for clinically relevant subdomains. Heterogeneity was determined with I².

Results: 121 papers were included for analyses. Data of 5 923 children with DCD were included (59.8% boys) and 23 619 Typically Developing (TD) children (45.8% boys). The mean (SD) age of the DCD group was 10.3y (1.2) and 9.3y (1.3) for the TD children. Moderate evidence was found for motor performance, executive functions, sensory processing and perceptions, cognitive functions and sports and leisure activities to be affected in children with DCD.

Conclusion: Differences between the two groups varied per domain of functioning. This emphasizes the diversity present within children with DCD and provides a rationale for explaining the heterogeneity in this patient group. Yet, results highlight the potential involvement of all these domains and call for clinicians to be alert not only to examine motor skill difficulties but also other aspects of function. Results indicate the need to develop an individualized pre-intervention multi-dimensional assessment profile for each child with DCD. It also supports the important role that clinicians play in an interdisciplinary team to tackle the difficulties encountered by children with DCD.

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哪些结果是发育协调障碍儿童干预前评估概况的关键？系统回顾与荟萃分析。

研究背景本研究的目的是确定在对发育协调障碍（DCD）儿童进行干预前评估时，应纳入哪些关键的功能方面；更具体地说，哪些功能方面与 DCD 有关，以及它们的相对影响是什么？对 Pubmed、Web of Science、Scopus 和 Proquest 进行了系统回顾和荟萃分析（最后更新时间：2023 年 4 月，PROSPERO：CRD42023461619）。其中包括病例对照研究，以确定不同功能领域的现场测试表现的点估计值。对偏倚风险进行了评估，并对证据水平进行了估计。进行随机效应荟萃分析以计算功能领域的集合标准化均值差异，并对临床相关的子领域进行分组。异质性用I2确定：共纳入 121 篇论文进行分析。共纳入了 5 923 名患有 DCD 的儿童（59.8% 为男孩）和 23 619 名发育正常（TD）儿童（45.8% 为男孩）的数据。DCD 组儿童的平均（标清）年龄为 10.3 岁（1.2），TD 组儿童的平均（标清）年龄为 9.3 岁（1.3）。研究发现，中等程度的证据表明，DCD儿童的运动表现、执行功能、感觉处理和知觉、认知功能以及运动和休闲活动会受到影响：结论：两组儿童在各个功能领域的差异各不相同。这强调了 DCD 儿童的多样性，并为解释这一患者群体的异质性提供了理论依据。然而，研究结果强调了所有这些领域的潜在参与性，并呼吁临床医生不仅要警惕运动技能方面的困难，还要注意功能的其他方面。研究结果表明，有必要为每名儿童发育迟缓症患者制定个性化的干预前多维评估档案。它还支持临床医生在跨学科团队中发挥重要作用，以解决 DCD 儿童遇到的困难。

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来源期刊

Biomedical Journal Medicine-General Medicine

CiteScore

11.60

自引率

1.80%

发文量

128

审稿时长

42 days

期刊介绍： Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs. Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology. A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.