Novel insight into MDA-7/IL-24: A potent therapeutic target for autoimmune and inflammatory diseases

IF 4.5 3区医学 Q2 IMMUNOLOGY Clinical immunology Pub Date : 2024-07-20 DOI:10.1016/j.clim.2024.110322

Kangni Feng, Jiemei Cen, Xiaoling Zou, Tiantuo Zhang

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Abstract

Melanoma differentiation-associated gene-7 (MDA-7)/interleukin-24 (IL-24) is a pleiotropic member of the IL-10 family of cytokines, and is involved in multiple biological processes, including cell proliferation, cell differentiation, tissue fibrosis, the inflammatory response, and antitumor activity. MDA-7/IL-24 can regulate epithelial integrity, homeostasis, mucosal immunity and host resistance to various pathogens by enhancing immune and inflammatory responses. Our recent study revealed the mechanism of MDA-7/IL-24 in promoting airway inflammation and airway remodeling through activating the JAK/STAT3 and ERK signaling pathways in bronchial epithelial cells. Herein, we summarize the cellular sources, inducers, target cells, signaling pathways, and biological effects of MDA-7/IL-24 in several allergic and autoimmune diseases. This review also synopsizes recent advances in clinical research targeting MDA-7/IL-24 or its receptors. Based on these advancements, we emphasize its potential as a target for immunotherapy and discuss the challenges of developing immunotherapeutic drugs targeting MDA-7/IL-24 or its receptors in autoimmune and inflammatory disorders.

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对 MDA-7/IL-24 的新认识：自身免疫性和炎症性疾病的强效治疗靶点

黑色素瘤分化相关基因-7（MDA-7）/白细胞介素-24（IL-24）是 IL-10 细胞因子家族中的多效成员，参与多种生物过程，包括细胞增殖、细胞分化、组织纤维化、炎症反应和抗肿瘤活性。MDA-7/IL-24 可通过增强免疫和炎症反应来调节上皮细胞的完整性、稳态、粘膜免疫和宿主对各种病原体的抵抗力。我们最近的研究揭示了 MDA-7/IL-24 通过激活支气管上皮细胞中的 JAK/STAT3 和 ERK 信号通路促进气道炎症和气道重塑的机制。在此，我们总结了 MDA-7/IL-24 在几种过敏性和自身免疫性疾病中的细胞来源、诱导剂、靶细胞、信号通路和生物效应。本综述还概述了针对 MDA-7/IL-24 或其受体的临床研究的最新进展。基于这些进展，我们强调了其作为免疫疗法靶点的潜力，并讨论了开发针对自身免疫性疾病和炎症性疾病的 MDA-7/IL-24 或其受体的免疫疗法药物所面临的挑战。

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来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.