Hysteroscopic Endometrial Fundal Incision versus Hysteroscopy Only in Oocyte Recipients: A Randomized Controlled Trial Assessing The Reproductive Outcomes.

IF 2.3 Q2 OBSTETRICS & GYNECOLOGY International Journal of Fertility & Sterility Pub Date : 2024-07-13 DOI:10.22074/ijfs.2024.2009369.1523
Nikolaos Peitsidis, Ioannis Tsakiridis, Robert Najdecki, Georgios Michos, Ioannis Kalogiannidis, Apostolos Athanasiadis, Evangelos Papanikolaou
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Abstract

Background: Endometrial scratching (ES) remains controversial regarding its potential effectiveness in improving pregnancy rates. The objective of the present study was to assess the impact of endometrial fundal incision (EFI) during hysteroscopy on reproductive outcomes in a population of oocyte recipients.

Materials and methods: A randomized controlled trial was conducted between 2020 and 2023 at the Third Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki and "Assisting Nature Centre of Reproduction and Genetics". The study population consisted of women who underwent hysteroscopy randomly assigned in a 1:1 ratio to either EFI (one to three months before embryotransfer with donor oocytes) or no intervention throughout office hysteroscopy. Clinical pregnancy and live birth rates were the primary outcomes.

Results: After the exclusion of patients with intraoperative diagnosed endometrial pathology, a total of 124 women underwent randomization. The pregnancy test was positive in 79% (n=49/62) of the women in the EFI compared to 59.7% (n=37/62) in the hysteroscopy-only group (P=0.019), while the live birth rates did not differ between the two groups (58.1%, n=36/62 vs. 51.6%, n=32/62, P=0.470).

Conclusion: EFI during hysteroscopy seems to improve pregnancy rates in oocyte recipients without intrauterine pathology, while live birth rates are not affected by the EFI. These results should be interpreted with caution before the implementation of EFI in the routine in vitro fertilization (IVF) practice (registration number: NCT04580056).

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宫腔镜子宫内膜基底切开术与仅宫腔镜检查卵母细胞受者:评估生殖结果的随机对照试验。
背景:子宫内膜搔刮术(ES)在提高妊娠率方面的潜在效果仍存在争议。本研究的目的是评估宫腔镜检查期间子宫内膜基底切口(EFI)对卵母细胞受体人群生殖结局的影响:塞萨洛尼基亚里士多德大学(Aristotle University of Thessaloniki)健康科学学院医学院妇产科第三系和 "生殖与遗传辅助自然中心 "于 2020 年至 2023 年期间开展了一项随机对照试验。研究对象包括接受宫腔镜检查的妇女,她们按 1:1 的比例被随机分配到 EFI(使用供体卵母细胞进行胚胎移植前 1 到 3 个月)或在整个宫腔镜检查期间不进行干预。临床妊娠率和活产率是主要结果:在排除术中诊断出子宫内膜病变的患者后,共有 124 名妇女接受了随机分组。EFI组中79%(n=49/62)的妇女妊娠试验呈阳性,而单纯宫腔镜组中59.7%(n=37/62)的妇女妊娠试验呈阳性(P=0.019),两组间的活产率无差异(58.1%,n=36/62 vs. 51.6%,n=32/62,P=0.470):结论:在宫腔镜检查过程中进行EFI似乎能提高无宫内病变的卵细胞受者的妊娠率,而EFI并不影响活产率。在常规体外受精(IVF)实践中实施 EFI 之前,应谨慎解释这些结果(注册号:NCT04580056)。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.
期刊最新文献
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