Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks.

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY Immunity & Ageing Pub Date : 2024-07-20 DOI:10.1186/s12979-024-00449-w
Anna Wadhwa, Maria Moreno-Villanueva, Brian Crucian, Honglu Wu
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Abstract

Spaceflight poses a myriad of environmental stressors to astronauts´ physiology including microgravity and radiation. The individual impacts of microgravity and radiation on the immune system have been extensively investigated, though a comprehensive review on their combined effects on immune system outcomes is missing. Therefore, this review aims at understanding the synergistic, additive, and antagonistic interactions between microgravity and radiation and their impact on immune function as observed during spaceflight-analog studies such as rodent hindlimb unloading and cell culture rotating wall vessel models. These mimic some, but not all, of the physiological changes observed in astronauts during spaceflight and provide valuable information that should be considered when planning future missions. We provide guidelines for the design of further spaceflight-analog studies, incorporating influential factors such as age and sex for rodent models and standardizing the longitudinal evaluation of specific immunological alterations for both rodent and cellular models of spaceflight exposure.

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辐射和微重力在航天相关免疫健康风险中的协同作用。
太空飞行给宇航员的生理带来了无数的环境压力,包括微重力和辐射。微重力和辐射对免疫系统的单独影响已经得到了广泛的研究,但关于它们对免疫系统结果的综合影响的全面综述还很缺乏。因此,本综述旨在了解微重力和辐射之间的协同、相加和拮抗作用及其对免疫功能的影响,正如在太空飞行模拟研究(如啮齿动物后肢卸载和细胞培养旋转壁血管模型)中所观察到的那样。这些模型模拟了宇航员在太空飞行期间观察到的部分(但不是全部)生理变化,并提供了在规划未来飞行任务时应考虑的宝贵信息。我们为设计进一步的太空飞行模拟研究提供了指导方针,将年龄和性别等影响因素纳入啮齿类动物模型,并对啮齿类动物和细胞太空飞行暴露模型的特定免疫学改变的纵向评估进行标准化。
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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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