Enamel matrix proteins in promoting saliva lubrication

IF 6.3 1区 工程技术 Q1 ENGINEERING, MECHANICAL Friction Pub Date : 2024-07-22 DOI:10.1007/s40544-024-0873-8
Hujun Wang, Yue Tang, Haonan Qiu, Jingyang Hu, Yuan Su, Jing Zheng, Zhongrong Zhou
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Abstract

Anti-wear performance of human enamel in the mouth is closely related to the lubrication of salivary pellicle. It is well known that the inorganic hydroxyapatite (HA) of the enamel plays an important role in the adsorption and pellicle-forming of salivary proteins on the enamel, but the role of enamel matrix proteins remains unclear. In this study, the adsorption and lubrication behavior of salivary proteins on original, heated, and deproteinated enamel surfaces was comparatively investigated using an atomic force microscopy and nano-indentation/scratch techniques. Compared with that on the original enamel surface, the adsorption and lubrication behavior of salivary proteins remains almost unchanged on the heated enamel surface (where the enamel matrix proteins are denatured but the size of HA crystalline nanoparticles keeps constant) but exhibits an obvious compromise on the deproteinated enamel surface (where the enamel matrix proteins are removed and agglomeration of HA crystallites occurs). The HA agglomeration weakens the electrostatic interaction of enamel surfaces with salivary proteins to cause a distinct negative influence on the adsorption and pellicle-forming of salivary proteins. Further, the negative effect is confirmed with a quartz crystal microbalance with dissipation. In summary, by regulating enamel nanostructure for appropriate electrostatic interactions between salivary proteins and enamel surfaces, the enamel matrix proteins play an essential role in the adsorption and pellicle-forming of salivary proteins on human enamel, and then contribute to saliva lubrication, which provides the enamel with an anti-wear mechanism. The findings will promote and assist the design of enamel-inspired anti-wear materials.

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促进唾液润滑的釉质基质蛋白
口腔中人体珐琅质的抗磨损性能与唾液胶粒的润滑作用密切相关。众所周知,珐琅质中的无机羟基磷灰石(HA)对唾液蛋白质在珐琅质上的吸附和胶粒形成起着重要作用,但珐琅质基质蛋白的作用仍不清楚。本研究使用原子力显微镜和纳米压痕/划痕技术比较研究了唾液蛋白质在原始釉质、加热釉质和脱蛋白釉质表面的吸附和润滑行为。与原始珐琅质表面相比,唾液蛋白在加热珐琅质表面(珐琅质基质蛋白变性,但 HA 纳米结晶颗粒的尺寸保持不变)的吸附和润滑行为几乎没有变化,但在去蛋白珐琅质表面(珐琅质基质蛋白被去除,HA 结晶颗粒发生团聚)则表现出明显的折衷。HA 凝聚削弱了釉质表面与唾液蛋白的静电相互作用,从而对唾液蛋白的吸附和胶粒形成产生了明显的负面影响。此外,石英晶体微天平也证实了这种负面影响。总之,通过调节釉质纳米结构以实现唾液蛋白与釉质表面之间适当的静电相互作用,釉质基质蛋白在唾液蛋白在人体釉质上的吸附和胶粒形成过程中发挥了重要作用,进而促进了唾液润滑,为釉质提供了抗磨损机制。这些发现将促进和帮助釉质抗磨材料的设计。
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来源期刊
Friction
Friction Engineering-Mechanical Engineering
CiteScore
12.90
自引率
13.20%
发文量
324
审稿时长
13 weeks
期刊介绍: Friction is a peer-reviewed international journal for the publication of theoretical and experimental research works related to the friction, lubrication and wear. Original, high quality research papers and review articles on all aspects of tribology are welcome, including, but are not limited to, a variety of topics, such as: Friction: Origin of friction, Friction theories, New phenomena of friction, Nano-friction, Ultra-low friction, Molecular friction, Ultra-high friction, Friction at high speed, Friction at high temperature or low temperature, Friction at solid/liquid interfaces, Bio-friction, Adhesion, etc. Lubrication: Superlubricity, Green lubricants, Nano-lubrication, Boundary lubrication, Thin film lubrication, Elastohydrodynamic lubrication, Mixed lubrication, New lubricants, New additives, Gas lubrication, Solid lubrication, etc. Wear: Wear materials, Wear mechanism, Wear models, Wear in severe conditions, Wear measurement, Wear monitoring, etc. Surface Engineering: Surface texturing, Molecular films, Surface coatings, Surface modification, Bionic surfaces, etc. Basic Sciences: Tribology system, Principles of tribology, Thermodynamics of tribo-systems, Micro-fluidics, Thermal stability of tribo-systems, etc. Friction is an open access journal. It is published quarterly by Tsinghua University Press and Springer, and sponsored by the State Key Laboratory of Tribology (TsinghuaUniversity) and the Tribology Institute of Chinese Mechanical Engineering Society.
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