The Optimal Cut-off Value of Upper Arm Circumference and Calf Circumference for Assessing Sarcopenia Among Chinese Community-Dwelling Older Adults

IF 3.6 3区医学 Clinical Interventions in Aging Pub Date : 2024-07-18 DOI:10.2147/cia.s468036

Mengli Li, Tongtong Yin, Jiaying Qi, Minhao Shi, Fangfang Wang, Zhiyu Mao, Hui Zhang, Li Wang

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Abstract

Objective: To explore the cut-off values and health evaluations of upper arm circumference (AC) and calf circumference (CC) on sarcopenia in Chinese community-dwelling older people.
Methods: In this cross-sectional study, AC, CC, handgrip strength, muscle mass and gait speed were measured in 1537 Chinese community-dwelling older people in Sub-study 1. Correlation analysis, receiver operator characteristic curve (ROC curve) analysis, and consistency analysis were used for determination of AC and CC cut-off values for sarcopenia diagnosis (sarcopenia-AC and CC). Thereafter, 269 participants accepted additional assessments on physical function, body composition and muscle strength in Sub-study 2. T-test or Mann-Whitney U-test was used to explore the differential effects of sarcopenia-AC and CC on health indicators between sarcopenic and non-sarcopenic participants.
Results: In Sub-study 1, the Area Under ROC (AUC) of AC and CC for sarcopenia screening were greater than 0.700 (P< 0.05). The cut-off values, sensitivity and specificity of AC and CC on sarcopenia in males were 25.9 cm (86.0%, 83.6%) and 33.7 cm (90.7%, 81.4%) whereas in females were 26.5 cm (70.8%, 69.7%) and 33.0 cm (86.5%, 69.4%), respectively. In Sub-study 2, the participants with sarcopenia-AC or sarcopenia-CC showed lower muscle strength and lower fat and muscle mass than the ones without (P< 0.05). Additionally, males instead of females with sarcopenia-AC or sarcopenia-CC showed worse performance in time-up and go test and 6-Minute Walk Test (P< 0.05). However, the 30-second chair stand test was not different between participants with and without sarcopenia-AC or sarcopenia-CC in both sexes.
Conclusion: We found accurate and Chinese population targeted cut-off values of AC and CC on sarcopenia diagnosis (25.9 cm and 33.7 cm in males; 26.5 cm and 33.0 cm in females) and a good evaluation effect of AC and CC on fat and muscle mass, muscle strength and physical functions in males, not females.

Keywords: sarcopenia, upper arm circumference, calf circumference, health assessment

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评估中国社区老年人 "肌肉疏松症 "时上臂围和小腿围的最佳临界值

目的探讨上臂围（AC）和小腿围（CC）对中国社区老年人肌少症的临界值和健康评价：在这项横断面研究中，子研究 1 测量了 1537 名中国社区老年人的 AC、CC、手握力、肌肉质量和步速。通过相关性分析、接收器操作者特征曲线（ROC 曲线）分析和一致性分析，确定了诊断肌少症的 AC 和 CC 临界值（肌少症-AC 和 CC）。此后，269 名参与者接受了子研究 2 中有关身体功能、身体成分和肌肉力量的额外评估。研究人员采用T检验或曼-惠尼U检验来探讨肌少症-AC和CC对肌少症和非肌少症参与者健康指标的不同影响：在子研究 1 中，AC 和 CC 的肌少症筛查 ROC 下面积均大于 0.700（P< 0.05）。AC 和 CC 对男性肌少症的临界值、敏感度和特异度分别为 25.9 厘米（86.0%，83.6%）和 33.7 厘米（90.7%，81.4%），而女性则分别为 26.5 厘米（70.8%，69.7%）和 33.0 厘米（86.5%，69.4%）。在次级研究 2 中，患有肌肉疏松症-AC 或肌肉疏松症-CC 的参与者的肌肉力量、脂肪和肌肉质量均低于未患有肌肉疏松症的参与者（P< 0.05）。此外，患有 "肌肉疏松症-交流性 "或 "肌肉疏松症-慢性 "的男性，而非女性，在 "计时起跑测试 "及 "6 分钟步行测试 "的表现较差（P< 0.05）。然而，在 30 秒椅子站立测试中，患有肌肉疏松症-AC 或肌肉疏松症-CC 的男女参与者的表现并无差异：我们发现了准确且符合中国人体质的上臂围和小腿围临界值（男性分别为 25.9 厘米和 33.7 厘米；女性分别为 26.5 厘米和 33.0 厘米），并且上臂围和小腿围对男性的脂肪和肌肉质量、肌肉力量和身体机能具有良好的评估效果。

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.20

自引率

2.80%

发文量

193

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.