Scalable DNA recognition circuits based on DNA strand displacement

Abstract

DNA is a kind of nano-molecule considered to be computable on the molecular level, and the precise Watson-Crick principle of base pairing has made it possible for DNA to be a novel computer material. The DNA strand displacement technology has greatly facilitated the development of DNA computing in both logical and intelligent computation. In this paper, we proposed and implemented a molecular recognition circuit based on DNA strand displacement, which can achieve recognition and summation functions. This circuit has a simple molecular composition and is easily scalable. A cross-inhalation module was integrated based upon the molecular recognition circuit to construct a molecular comparator. Considering the advantages of modularity and the experimental feasibility of scalable recognition circuit, it could be used as pattern signal recognition and classification module in smart molecular circuits or biosensors.