Scalable DNA recognition circuits based on DNA strand displacement†

Abstract

DNA is a kind of nano-molecule considered to be computable on the molecular level, and the precise Watson-Crick principle of base pairing has made it possible for DNA to be a novel computer material. The DNA strand displacement technology has greatly facilitated the development of DNA computing in both logical and intelligent computation. In this paper, we proposed and implemented a molecular recognition circuit based on DNA strand displacement, which can achieve recognition and summation functions. This circuit has a simple molecular composition and is easily scalable. A cross-inhibition module was integrated based upon the molecular recognition circuit to construct a molecular comparator. Considering the advantages of modularity and the experimental feasibility of a scalable recognition circuit, it could be used as a pattern signal recognition and classification module in smart molecular circuits or biosensors.