[Retrospective study on the impact of penile corpus cavernosum injection test on penile vascular function].

Q3 Medicine 北京大学学报（医学版） Pub Date : 2024-08-18

Yan Chen, Kuangmeng Li, Kai Hong, Shudong Zhang, Jianxing Cheng, Zhongjie Zheng, Wenhao Tang, Lianming Zhao, Haitao Zhang, Hui Jiang, Haocheng Lin

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引用次数: 0

Abstract

Objective: To investigate the impact of age, various hormonal levels, and biochemical markers on penile cavernous body vascular function in patients with erectile dysfunction (ED). Me-thods: A retrospective analysis of clinical data from male patients with ED who underwent color duplex Doppler ultrasonography (CDDU) and intracavernosal injection test (ICI) at the Reproductive Medicine Center of Peking University Third Hospital from January 2020 to August 2023. Data were managed and processed using SPSS 29.0, and a multivariable Logistic regression analysis was conducted.

Results: A total of 700 ED patients were included, with 380 showing negative ICI results and 320 positive. In the study, 84 patients had a peak systolic velocity (PSV) < 25 cm/s, while 616 had PSV≥25 cm/s; 202 patients had end-diastolic velocity (EDV)>5 cm/s, and 498 had EDV≤5 cm/s. 264 patients had abnormal PSV and/or EDV results, and 436 had normal results for both. Patients with vascular ED had significantly lower estrogen levels (t=-3.546, P < 0.001), lower testosterone levels (t=-2.089, P=0.037), and a higher rate of hyperglycemia (χ²=12.772, P=0.002) compared with those with non-vascular ED. The patients with arterial ED were older (t=3.953, P < 0.001), had a higher rate of hyperglycemia (χ²=9.518, P=0.009), and a higher estrogen/testosterone ratio (t=2.330, P=0.020) compared with those with non-arterial ED. The patients with mixed arteriovenous ED had higher age (t=3.567, P < 0.001), lower testosterone levels (t=-2.288, P=0.022), a higher rate of hyperglycemia (χ²=12.877, P=0.002), and a larger estrogen/testosterone ratio (t=2.096, P=0.037) compared with those with normal findings. Multifactorial Logistic regression analysis indicated that higher levels of estrogen were a protective factor for vascular ED (OR=1.009, 95%CI: 1.004-1.014), and glucose≥7.0 mmol/L was a risk factor (OR=0.381, 95%CI: 0.219-0.661). Older age was a risk factor for arterial ED (OR=0.960, 95%CI: 0.938-0.982). Additionally, older age (OR=0.976, 95%CI: 0.958-0.993) and glucose levels of 5.6-6.9 mmol/L (OR=0.591, 95%CI: 0.399-0.876) were also risk factors for mixed arterio-venous ED.

Conclusion: Hyperglycemia and aging may impair penile cavernous body vascular function, while higher levels of estrogen may have a protective effect on it.

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[阴茎海绵体注射试验对阴茎血管功能影响的回顾性研究]。

目的研究年龄、各种激素水平和生化指标对勃起功能障碍（ED）患者阴茎海绵体血管功能的影响。方法：回顾性分析2020年1月至2023年8月在北京大学第三医院生殖医学中心接受彩色双工多普勒超声检查（CDDU）和阴茎海绵体内注射试验（ICI）的男性ED患者的临床数据。数据使用 SPSS 29.0 进行管理和处理，并进行了多变量 Logistic 回归分析：共纳入 700 名急诊科患者，其中 380 名患者的 ICI 结果为阴性，320 名患者为阳性。研究中，84 名患者的收缩期峰值速度（PSV）< 25 cm/s，616 名患者的 PSV≥25 cm/s；202 名患者的舒张末期速度（EDV）>5 cm/s，498 名患者的 EDV≤5 cm/s。264名患者的 PSV 和/或 EDV 结果异常，436 名患者的 PSV 和/或 EDV 结果均正常。与非血管性 ED 患者相比，血管性 ED 患者的雌激素水平明显较低（t=-3.546，P<0.001），睾酮水平较低（t=-2.089，P=0.037），高血糖发生率较高（χ2=12.772，P=0.002）。与非动脉性 ED 患者相比，动脉性 ED 患者年龄更大（t=3.953，P<0.001），高血糖率更高（χ2=9.518，P=0.009），雌激素/睾酮比率更高（t=2.330，P=0.020）。与检查结果正常的患者相比，混合性动静脉 ED 患者的年龄更高（t=3.567，P<0.001），睾酮水平更低（t=-2.288，P=0.022），高血糖发生率更高（χ2=12.877，P=0.002），雌激素/睾酮比值更大（t=2.096，P=0.037）。多因素 Logistic 回归分析表明，较高水平的雌激素是血管性 ED 的保护因素（OR=1.009，95%CI：1.004-1.014），而葡萄糖≥7.0 mmol/L 是风险因素（OR=0.381，95%CI：0.219-0.661）。年龄较大是动脉 ED 的危险因素（OR=0.960，95%CI：0.938-0.982）。此外，年龄较大（OR=0.976，95%CI：0.958-0.993）和血糖水平为 5.6-6.9 mmol/L（OR=0.591，95%CI：0.399-0.876）也是动静脉混合型 ED 的危险因素：结论：高血糖和衰老可能会损害阴茎海绵体血管功能，而较高水平的雌激素可能对其有保护作用。

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来源期刊

北京大学学报（医学版） Medicine-Medicine (all)

CiteScore

0.80

自引率

0.00%

发文量

9815

期刊介绍： Beijing Da Xue Xue Bao Yi Xue Ban / Journal of Peking University (Health Sciences), established in 1959, is a national academic journal sponsored by Peking University, and its former name is Journal of Beijing Medical University. The coverage of the Journal includes basic medical sciences, clinical medicine, oral medicine, surgery, public health and epidemiology, pharmacology and pharmacy. Over the last few years, the Journal has published articles and reports covering major topics in the different special issues (e.g. research on disease genome, theory of drug withdrawal, mechanism and prevention of cardiovascular and cerebrovascular diseases, stomatology, orthopaedic, public health, urology and reproductive medicine). All the topics involve latest advances in medical sciences, hot topics in specific specialties, and prevention and treatment of major diseases. The Journal has been indexed and abstracted by PubMed Central (PMC), MEDLINE/PubMed, EBSCO, Embase, Scopus, Chemical Abstracts (CA), Western Pacific Region Index Medicus (WPR), JSTChina, and almost all the Chinese sciences and technical index systems, including Chinese Science and Technology Paper Citation Database (CSTPCD), Chinese Science Citation Database (CSCD), China BioMedical Bibliographic Database (CBM), CMCI, Chinese Biological Abstracts, China National Academic Magazine Data-Base (CNKI), Wanfang Data (ChinaInfo), etc.