Albumin-Lymphocyte-Globulin-C-Reactive Protein Index as a Novel Prognostic Biomarker for Hepatocellular Carcinoma after Hepatectomy.

IF 1.8 3区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Digestive Surgery Pub Date : 2024-01-01 Epub Date: 2024-07-22 DOI:10.1159/000540067

Masashi Utsumi, Masaru Inagaki, Koji Kitada, Naoyuki Tokunaga, Kosuke Yunoki, Yuya Sakurai, Hiroki Okabayashi, Ryosuke Hamano, Hideaki Miyaso, Yosuke Tsunemitsu, Shinya Otsuka

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Abstract

Introduction: This study evaluated the performance of the albumin-lymphocyte-globulin-C-reactive protein (CRP) (ALGC) index as a novel prognostic biomarker for hepatocellular carcinoma (HCC) after hepatectomy.

Methods: Patients (n = 178) who underwent hepatectomy for HCC (July 2010-December 2021) were analyzed. The ALGC index was calculated as ([albumin × lymphocyte]/[CRP × globulin × 104]). Patients were divided into a low ALGC group (<1.82; n = 81) and a high ALGC group (≥1.82; n = 97). The association of the ALGC index with survival was assessed by univariate and multivariate analyses.

Results: The median overall survival (OS) was 100 (range: 1-149) months with 1-, 3-, and 5-year OS rates of 91.6%, 81.2%, and 64.2%, respectively. In univariate analysis, ALGC index (<1.82), alpha-fetoprotein (≥25 ng/mL), tumor size (≥3.5 cm), microvascular invasion, and multiple tumors were associated with shorter OS. ALGC index (<1.82) (hazard ratio [95% confidence interval]) (2.48 [1.407-4.513]; p = 0.001) and multiple tumors (1.92 [1.070-3.356]; p = 0.029) were independent predictors of OS in multivariate analysis.

Conclusion: ALGC index is a novel prognostic biomarker for HCC after hepatectomy. It may assist in treatment stratification and better management of patients with HCC.

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白蛋白-淋巴细胞-球蛋白-C-反应蛋白指数作为肝切除术后肝细胞癌的新型预后生物标志物

简介本研究评估了白蛋白-淋巴细胞-球蛋白-C反应蛋白（CRP）（ALGC）指数作为肝细胞癌（HCC）肝切除术后新型预后生物标志物的性能：方法：对2010年7月至2021年12月接受肝切除术的HCC患者（178人）进行分析。ALGC指数的计算公式为[（白蛋白×淋巴细胞）/（CRP×球蛋白×104）]。患者被分为低ALGC组（<1.82; n=81）和高ALGC组（≥1.82; n=97）。通过单变量和多变量分析评估了ALGC指数与生存期的关系：中位总生存期（OS）为100个月（范围：1-149），1年、3年和5年OS率分别为91.6%、81.2%和64.2%。在单变量分析中，ALGC指数（<1.82）、甲胎蛋白（≥25纳克/毫升）、肿瘤大小（≥3.5厘米）、微血管侵犯和多发肿瘤与较短的OS相关。在多变量分析中，ALGC指数（<1.82）（危险比[95%置信区间]）（2.48 [1.407-4.513]; P=0.001）和多发肿瘤（1.92 [1.070-3.356]; P=0.029）是OS的独立预测因素：结论：ALGC指数是肝切除术后HCC的新型预后生物标志物。结论：ALGC指数是肝切除术后HCC的一种新的预后生物标志物，有助于对HCC患者进行治疗分层和更好的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive Surgery 医学-外科

CiteScore

4.90

自引率

3.70%

发文量

审稿时长

3 months

期刊介绍： ''Digestive Surgery'' presents a comprehensive overview in the field of gastrointestinal surgery. Interdisciplinary in scope, the journal keeps the specialist aware of advances in all fields that contribute to improvements in the diagnosis and treatment of gastrointestinal disease. Particular emphasis is given to articles that evaluate not only recent clinical developments, especially clinical trials and technical innovations such as new endoscopic and laparoscopic procedures, but also relevant translational research. Each contribution is carefully aligned with the need of the digestive surgeon. Thus, the journal is an important component of the continuing medical education of surgeons who want their practice to benefit from a familiarity with new knowledge in all its dimensions.