Changyong Yu;Dekuan Gao;Xu Guo;Haitao Ma;Yuhai Zhao;Guoren Wang
{"title":"dwMLCS: An Efficient MLCS Algorithm Based on Dynamic and Weighted Directed Acyclic Graph","authors":"Changyong Yu;Dekuan Gao;Xu Guo;Haitao Ma;Yuhai Zhao;Guoren Wang","doi":"10.1109/TCBB.2024.3431558","DOIUrl":null,"url":null,"abstract":"The problem of finding the longest common subsequence (MLCS) for multiple sequences is a computationally intensive and challenging problem that has significant applications in various fields such as text comparison, pattern recognition, and gene diagnosis. Currently, the dominant point-based MLCS algorithms have become popular and extensively studied. Generally, they construct the directed acyclic graph (DAG) of matching points and convert the MLCS problem into a search for the longest paths in the DAG. Several improvements have been made, focusing on decreasing model size and reducing redundant computations. These include 1) hash methods for eliminating duplicated nodes, 2) dynamic structures for supporting smaller DAG and 3) path pruning strategy and so on. However, the algorithms are still too limited when facing large-scale MLCS problem due to 1) the dynamic structures are too time-consuming to maintain and 2) the path pruning relies heavily on the tightness of the lower and upper bound of the MLCS. These factors contribute to the large-scale MLCS problem remaining a challenge. We propose a novel algorithm for the large-scale MLCS problem, named dwMLCS. It is based on two models: one is a dynamic DAG model which is both space and time efficient. It can decrease the size of the DAG significantly. The other is a weighted DAG model with new successor strategies. With this model, we design the algorithm for finding a tighter lower bound of the MLCS. Then, the path pruning is conducted to further reduce the size of the DAG and eliminate redundant computation. Additionally, we propose an upper bound method for improving the efficiency of the path pruning strategy. The experimental results demonstrate that the effectiveness and efficiency of the models and algorithms proposed are better than state-of-the-art algorithms.","PeriodicalId":13344,"journal":{"name":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","volume":"21 6","pages":"1987-1999"},"PeriodicalIF":3.6000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE/ACM Transactions on Computational Biology and Bioinformatics","FirstCategoryId":"5","ListUrlMain":"https://ieeexplore.ieee.org/document/10606065/","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
The problem of finding the longest common subsequence (MLCS) for multiple sequences is a computationally intensive and challenging problem that has significant applications in various fields such as text comparison, pattern recognition, and gene diagnosis. Currently, the dominant point-based MLCS algorithms have become popular and extensively studied. Generally, they construct the directed acyclic graph (DAG) of matching points and convert the MLCS problem into a search for the longest paths in the DAG. Several improvements have been made, focusing on decreasing model size and reducing redundant computations. These include 1) hash methods for eliminating duplicated nodes, 2) dynamic structures for supporting smaller DAG and 3) path pruning strategy and so on. However, the algorithms are still too limited when facing large-scale MLCS problem due to 1) the dynamic structures are too time-consuming to maintain and 2) the path pruning relies heavily on the tightness of the lower and upper bound of the MLCS. These factors contribute to the large-scale MLCS problem remaining a challenge. We propose a novel algorithm for the large-scale MLCS problem, named dwMLCS. It is based on two models: one is a dynamic DAG model which is both space and time efficient. It can decrease the size of the DAG significantly. The other is a weighted DAG model with new successor strategies. With this model, we design the algorithm for finding a tighter lower bound of the MLCS. Then, the path pruning is conducted to further reduce the size of the DAG and eliminate redundant computation. Additionally, we propose an upper bound method for improving the efficiency of the path pruning strategy. The experimental results demonstrate that the effectiveness and efficiency of the models and algorithms proposed are better than state-of-the-art algorithms.
期刊介绍:
IEEE/ACM Transactions on Computational Biology and Bioinformatics emphasizes the algorithmic, mathematical, statistical and computational methods that are central in bioinformatics and computational biology; the development and testing of effective computer programs in bioinformatics; the development of biological databases; and important biological results that are obtained from the use of these methods, programs and databases; the emerging field of Systems Biology, where many forms of data are used to create a computer-based model of a complex biological system