Geriatric nutritional risk index as a predictor for surgical site infection in malignant musculoskeletal tumours of the trunk.

IF 1.9 4区 医学 Q3 ONCOLOGY Japanese journal of clinical oncology Pub Date : 2024-11-02 DOI:10.1093/jjco/hyae095
Sakura Shiraishi, Toshifumi Fujiwara, Akira Nabeshima, Keiichiro Iida, Makoto Endo, Yoshihiro Matsumoto, Yoshinao Oda, Yasuharu Nakashima
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Abstract

Background and objective: Surgical site infection (SSI) is common in surgery for malignant musculoskeletal tumours, specifically those arising from the trunk. In this study, we investigated the risk factors for SSI after resection of musculoskeletal tumours of the trunk.

Methods: This retrospective observational study included 125 patients (72 males, 53 females) with musculoskeletal tumours of the trunk in our hospital from 1 April 2008 to 31 August 2023. The incidence of SSI and its risk factors were investigated.

Results: SSI was observed in 26% (32/125), and the median time to SSI was 22 days. On multivariate analysis, the following were identified as risk factors for SSI: tumours arising caudal to Jacoby's line (hazard ratio [HR] 4.04; P = .0107), soft tissue reconstruction (HR 3.43; P = .0131), and low Geriatric Nutritional Risk Index (GNRI) (HR 0.96; P = .0304). Patients were classified into two risk categories based on GNRI scores: the risk group (GNRI ≤98) and no risk group (>98). The risk group showed a significantly lower overall noninfection survival rate (P = .023).

Conclusion: Tumours arising caudal to Jacoby line, soft tissue reconstruction, and lower GNRI were risk factors for SSI. Preoperative and postoperative nutritional interventions should be considered to improve GNRI.

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预测躯干恶性肌肉骨骼肿瘤手术部位感染的老年营养风险指数。
背景和目的:手术部位感染(SSI)是恶性肌肉骨骼肿瘤手术中的常见病,尤其是躯干肿瘤。在这项研究中,我们调查了躯干肌肉骨骼肿瘤切除术后发生 SSI 的风险因素:这项回顾性观察研究纳入了我院 2008 年 4 月 1 日至 2023 年 8 月 31 日期间 125 例躯干肌肉骨骼肿瘤患者(男 72 例,女 53 例)。研究调查了 SSI 的发生率及其风险因素:结果:26%(32/125)的患者出现 SSI,SSI 的中位时间为 22 天。经多变量分析,以下因素被确定为SSI的风险因素:肿瘤位于雅各比线尾部(危险比[HR]4.04;P = .0107)、软组织重建(HR 3.43;P = .0131)和老年营养风险指数(GNRI)低(HR 0.96;P = .0304)。根据 GNRI 分数将患者分为两个风险类别:风险组(GNRI ≤98)和无风险组(>98)。风险组的非感染总生存率明显较低(P = .023):结论:雅各比线尾部的肿瘤、软组织重建和较低的 GNRI 是 SSI 的风险因素。应考虑进行术前和术后营养干预,以提高 GNRI。
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来源期刊
CiteScore
3.70
自引率
8.30%
发文量
177
审稿时长
3-8 weeks
期刊介绍: Japanese Journal of Clinical Oncology is a multidisciplinary journal for clinical oncologists which strives to publish high quality manuscripts addressing medical oncology, clinical trials, radiology, surgery, basic research, and palliative care. The journal aims to contribute to the world"s scientific community with special attention to the area of clinical oncology and the Asian region. JJCO publishes various articles types including: ・Original Articles ・Case Reports ・Clinical Trial Notes ・Cancer Genetics Reports ・Epidemiology Notes ・Technical Notes ・Short Communications ・Letters to the Editors ・Solicited Reviews
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