Venous thromboembolism in patients undergoing surgery for lung cancer: a post hoc analysis of the Cancer-VTE Registry.

IF 1.9 4区 医学 Q3 ONCOLOGY Japanese journal of clinical oncology Pub Date : 2024-11-02 DOI:10.1093/jjco/hyae090
Riken Kawachi, Tetsuya Okano, Nobuyasu Awano, Masaru Matsumoto, Jun Hosokawa, Atsushi Takita, Mari S Oba, Hideo Kunitoh
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Abstract

The relationship between lung cancer surgery and venous thromboembolism (VTE) in Japan has not been elucidated. This was a post hoc analysis of the Cancer-VTE Registry. The 1057 patients who underwent surgery for lung cancer were divided into the surgery alone (SA) group (n = 598) and the surgery plus chemotherapy (SC) group (n = 459), and the 1-year incidences of VTE and cerebral ischemia were analyzed. In the SA and SC groups, composite VTE was observed in one (0.2%) and 15 (3.3%) patients, respectively, and cerebral ischemia was observed in eight (1.3%) and four (0.9%) patients, respectively. Lymph node metastasis was more common in patients with D-dimer >1.2 μg/ml (odds ratio: 1.781, P = .004). SA had a low risk of VTE but a high risk of cerebral ischemia. Chemotherapy increases the risk of VTE. The D-dimer level was related to VTE and advanced cancer.

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肺癌手术患者的静脉血栓栓塞症:对癌症-VTE登记处的事后分析。
日本尚未阐明肺癌手术与静脉血栓栓塞(VTE)之间的关系。这是对癌症-VTE 登记进行的一项事后分析。1057 名接受肺癌手术的患者被分为单纯手术(SA)组(598 人)和手术加化疗(SC)组(459 人),并分析了 VTE 和脑缺血的 1 年发病率。在SA组和SC组中,分别有1例(0.2%)和15例(3.3%)患者出现复合VTE,分别有8例(1.3%)和4例(0.9%)患者出现脑缺血。淋巴结转移在D-二聚体大于1.2 μg/ml的患者中更为常见(几率比:1.781,P = .004)。SA发生VTE的风险较低,但发生脑缺血的风险较高。化疗会增加 VTE 的风险。D-二聚体水平与 VTE 和晚期癌症有关。
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来源期刊
CiteScore
3.70
自引率
8.30%
发文量
177
审稿时长
3-8 weeks
期刊介绍: Japanese Journal of Clinical Oncology is a multidisciplinary journal for clinical oncologists which strives to publish high quality manuscripts addressing medical oncology, clinical trials, radiology, surgery, basic research, and palliative care. The journal aims to contribute to the world"s scientific community with special attention to the area of clinical oncology and the Asian region. JJCO publishes various articles types including: ・Original Articles ・Case Reports ・Clinical Trial Notes ・Cancer Genetics Reports ・Epidemiology Notes ・Technical Notes ・Short Communications ・Letters to the Editors ・Solicited Reviews
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