Evaluation of the Urine POC-CCA Test Accuracy in the Detection of Schistosoma mansoni Infection: A Systematic Review and Meta-Analysis.

IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Tropical Medicine Pub Date : 2024-07-15 eCollection Date: 2024-01-01 DOI:10.1155/2024/5531687
Getaneh Alemu, Endalkachew Nibret
{"title":"Evaluation of the Urine POC-CCA Test Accuracy in the Detection of <i>Schistosoma mansoni</i> Infection: A Systematic Review and Meta-Analysis.","authors":"Getaneh Alemu, Endalkachew Nibret","doi":"10.1155/2024/5531687","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Schistosomiasis is a common public health problem throughout the world and <i>Schistosoma mansoni</i> is the most prevalent species in Africa. Most endemic countries use the Kato-Katz (KK) stool smear examination for diagnosis, mapping, and monitoring of intervention programs. However, its poor sensitivity calls for an urgency to evaluate and use more accurate diagnostic tools, of which detection of circulating cathodic antigen (CCA) in urine seems promising.</p><p><strong>Methods: </strong>Studies published until May 2022 were searched from PubMed, Google Scholar, and grey literature for systematic review and meta-analysis following the PRISMA guideline. Eligible studies were selected based on preset inclusion and exclusion criteria. Quality of included studies was assessed using the QUADAS-2 tool. Heterogeneity between studies was assessed using Cochrane <i>Q</i> test and <i>I</i> <sup>2</sup> test statistics. Data were analyzed using Review Manager 5.4.1 and Meta-DiSc 1.4 software programs.</p><p><strong>Results: </strong>Thirty-seven studies published in 29 papers and enrolling 21159 study participants were included for analysis. Overall analysis of Point-of-Care Circulating Cathodic Antigen (POC-CCA) test against KK reference standard revealed a pooled sensitivity and specificity of 0.86 (95% CI: 0.85-0.87) and 0.66 (95% CI: 0.65-0.67), respectively. Subgroup analysis among 24 studies comparing single POC-CCA with test single KK revealed a high sensitivity (0.88) but low specificity (0.66). Based on findings of 24 studies, the area under the curve (AUC) for the systematic receiver operating characteristic (SROC) curve was 0.7805, indicating that the POC-CCA test effectively separates those with the disease from those who do not have it. Higher sensitivity estimates of 0.93 and 0.90 were reported when comparisons were made between test results of 2 urine and 1 stool samples, and 3 urine and 3 stool samples, respectively. Single POC-CCA test resulted in a pooled sensitivity estimate of 0.81 (95% CI: 0.78-0.84) as evaluated by the polymerase chain reaction (PCR) reference test.</p><p><strong>Conclusions: </strong>The POC-CCA test has higher sensitivity than KK and may serve as a routine diagnostic alternative for disease diagnosis, mapping, and monitoring of interventions. However, its accuracy should further be evaluated at different transmission settings and infection intensity.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2024 ","pages":"5531687"},"PeriodicalIF":2.1000,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262874/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Tropical Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2024/5531687","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Schistosomiasis is a common public health problem throughout the world and Schistosoma mansoni is the most prevalent species in Africa. Most endemic countries use the Kato-Katz (KK) stool smear examination for diagnosis, mapping, and monitoring of intervention programs. However, its poor sensitivity calls for an urgency to evaluate and use more accurate diagnostic tools, of which detection of circulating cathodic antigen (CCA) in urine seems promising.

Methods: Studies published until May 2022 were searched from PubMed, Google Scholar, and grey literature for systematic review and meta-analysis following the PRISMA guideline. Eligible studies were selected based on preset inclusion and exclusion criteria. Quality of included studies was assessed using the QUADAS-2 tool. Heterogeneity between studies was assessed using Cochrane Q test and I 2 test statistics. Data were analyzed using Review Manager 5.4.1 and Meta-DiSc 1.4 software programs.

Results: Thirty-seven studies published in 29 papers and enrolling 21159 study participants were included for analysis. Overall analysis of Point-of-Care Circulating Cathodic Antigen (POC-CCA) test against KK reference standard revealed a pooled sensitivity and specificity of 0.86 (95% CI: 0.85-0.87) and 0.66 (95% CI: 0.65-0.67), respectively. Subgroup analysis among 24 studies comparing single POC-CCA with test single KK revealed a high sensitivity (0.88) but low specificity (0.66). Based on findings of 24 studies, the area under the curve (AUC) for the systematic receiver operating characteristic (SROC) curve was 0.7805, indicating that the POC-CCA test effectively separates those with the disease from those who do not have it. Higher sensitivity estimates of 0.93 and 0.90 were reported when comparisons were made between test results of 2 urine and 1 stool samples, and 3 urine and 3 stool samples, respectively. Single POC-CCA test resulted in a pooled sensitivity estimate of 0.81 (95% CI: 0.78-0.84) as evaluated by the polymerase chain reaction (PCR) reference test.

Conclusions: The POC-CCA test has higher sensitivity than KK and may serve as a routine diagnostic alternative for disease diagnosis, mapping, and monitoring of interventions. However, its accuracy should further be evaluated at different transmission settings and infection intensity.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
评估尿液 POC-CCA 检测曼氏血吸虫感染的准确性:系统回顾与元分析》。
背景:血吸虫病是全世界常见的公共卫生问题,曼氏血吸虫是非洲最流行的血吸虫病种。大多数血吸虫病流行国家使用卡托-卡茨(KK)粪便涂片检查法进行诊断、绘图和监测干预计划。然而,其灵敏度较低,因此迫切需要评估和使用更准确的诊断工具,其中检测尿液中的循环阴性抗原(CCA)似乎很有前景:方法:按照PRISMA指南,从PubMed、谷歌学术和灰色文献中检索2022年5月之前发表的研究,进行系统综述和荟萃分析。根据预设的纳入和排除标准筛选出符合条件的研究。采用 QUADAS-2 工具对纳入研究的质量进行评估。研究之间的异质性采用 Cochrane Q 检验和 I 2 检验统计进行评估。数据使用 Review Manager 5.4.1 和 Meta-DiSc 1.4 软件进行分析:结果:共纳入了 29 篇论文中发表的 37 项研究,21159 名研究参与者参与了分析。对护理点循环阴道抗原(POC-CCA)检测与 KK 参考标准的总体分析表明,汇总的敏感性和特异性分别为 0.86(95% CI:0.85-0.87)和 0.66(95% CI:0.65-0.67)。对比较单一 POC-CCA 和单一 KK 检测的 24 项研究进行分组分析后发现,两者的灵敏度较高(0.88),但特异性较低(0.66)。根据 24 项研究的结果,系统接收者操作特征曲线(SROC)的曲线下面积(AUC)为 0.7805,表明 POC-CCA 检验能有效区分患病者和未患病者。在对 2 份尿液样本和 1 份粪便样本以及 3 份尿液样本和 3 份粪便样本的检测结果进行比较时,灵敏度估计值分别为 0.93 和 0.90。根据聚合酶链反应(PCR)参考测试的评估,单次 POC-CCA 检验的集合灵敏度估计值为 0.81(95% CI:0.78-0.84):结论:POC-CCA 检验的灵敏度高于 KK,可作为疾病诊断、绘图和干预监测的常规诊断替代方法。不过,其准确性还需在不同的传播环境和感染强度下进一步评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Tropical Medicine
Journal of Tropical Medicine Immunology and Microbiology-Parasitology
CiteScore
3.90
自引率
4.50%
发文量
0
审稿时长
14 weeks
期刊介绍: Journal of Tropical Medicine is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of tropical diseases. Articles on the pathology, diagnosis, and treatment of tropical diseases, parasites and their hosts, epidemiology, and public health issues will be considered. Journal of Tropical Medicine aims to facilitate the communication of advances addressing global health and mortality relating to tropical diseases.
期刊最新文献
Antiplasmodial Activity of Probiotic Limosilactobacillus fermentum YZ01 in Plasmodium berghei ANKA Infected BALB/c Mice. Epidemiology of Multidrug-Resistant Salmonella Typhi and Paratyphi Isolated From Stool Culture. Snakebite Envenomation From the Large Palearctic Viper, Macrovipera razii (Squamata: Serpentes; Viperidae), in Fars Province, Southern Iran. Determinants of Visceral Leishmaniasis in Addis Zemen Health Center, Northwest Ethiopia. Exploring the Antimalarial Potential of Gnetum gnemon Leaf Extract Against Plasmodium berghei in Mice.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1