Expression of the laminin genes family and its relationship to prognosis in pancreatic carcinoma

IF 1.1 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Arab Journal of Gastroenterology Pub Date : 2024-08-01 DOI:10.1016/j.ajg.2024.07.006
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Abstract

Background and study aims

Laminin is an extracellular matrix molecule that is the major component of the basement membrane and plays a key role in regulating various processes. However, the association between the laminin gene family and the prognosis of pancreatic carcinoma has not been systematically investigated.

Patients and methods

The role of the laminin gene family in pancreatic cancer was evaluated using data from the TCGA database. The effects of different expressions of members of the laminin gene family on pancreatic cancer survival were compared, and their primary cellular roles were examined. The effects of different expressions of positive family genes on proliferation, metastasis, and invasion, as well as EMT and ferroptosis in pancreatic cancer, were also examined.

Results

Based on univariate and multifactorial analysis of pancreatic cancer patients, LAMA3 was identified as an independent prognostic factor for overall survival in pancreatic cancer. LAMA3 was found to be enriched in the actin cytoskeleton, P53 signaling pathway, adhesion molecule junctions, pentose phosphate pathway, and regulatory differences in the cell cycle and focal adhesion. Additionally, high expression of LAMA3 was found to promote cancer proliferation, invasion, and metastasis, facilitate the EMT process, and inhibit ferroptosis.

Conclusions

Our results identified LAMA3 was associated with the prognosis of patients with pancreatic cancer and may serve as a prognostic biomarker for pancreatic cancer.

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胰腺癌中层粘蛋白基因家族的表达及其与预后的关系。
背景和研究目的:层粘连蛋白是一种细胞外基质分子,是基底膜的主要成分,在调节各种过程中发挥着关键作用。然而,层粘连蛋白基因家族与胰腺癌预后之间的关联尚未得到系统研究:利用 TCGA 数据库的数据评估了层粘连蛋白基因家族在胰腺癌中的作用。比较了层粘连蛋白基因家族成员的不同表达对胰腺癌生存率的影响,并研究了它们的主要细胞作用。此外,还研究了阳性家族基因的不同表达对胰腺癌的增殖、转移和侵袭以及EMT和铁变态反应的影响:结果:基于对胰腺癌患者的单变量和多因素分析,LAMA3被确定为胰腺癌总生存期的独立预后因素。研究发现,LAMA3富集于肌动蛋白细胞骨架、P53信号通路、粘附分子连接、磷酸戊糖通路以及细胞周期和病灶粘附的调控差异中。此外,研究还发现 LAMA3 的高表达可促进癌症的增殖、侵袭和转移,促进 EMT 过程,并抑制铁凋亡:我们的研究结果表明,LAMA3 与胰腺癌患者的预后有关,可作为胰腺癌的预后生物标志物。
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来源期刊
Arab Journal of Gastroenterology
Arab Journal of Gastroenterology Medicine-Gastroenterology
CiteScore
2.70
自引率
0.00%
发文量
52
期刊介绍: Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.
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