Recent advancement and trends in the development of membranes having bactericidal attributes via direct ink writing.

Himanshu Lanke, Jigar Patadiya, Barnali Banerjee, Balasubramanian Kandasubramanian
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Abstract

The necessity for orthopedic prostheses, implants, and membranes to treat diseases, trauma, and other disasters has increased as the risk of survive through various factors has intensified exponentially. Considering exponential growth in demand, it has been observed that the traditional technology of grafts and membranes lags to fulfill the demand and effectiveness simultaneously. These challenges in traditional methodologies prompted a revolutionary shift in the biomedical industry when additive manufacturing (AM) emerged as an alternative fabrication technique for medical equipments such as prostheses, implants, and membranes. However these techniques were fast and precise the major attributes of the biomedical materials were the processability, bactericidal nature, biocompatibility, biodegradability, and nontoxicity together with good mechanical properties. Major challenges faced by researchers in the present-day scenario regarding materials are the lack of bactericidal attributes in tailored material, though having better mechanical as well as biocompatible properties, which, on the other hand, are primary critical factors too, in the healthcare sector. Hence considering the advantages of AM and need for membranes with bacteriacidal attributes this present review will highlight the studies based on the manufacturing of membranes with bacteria-resistant properties majorly using direct ink writing and some AM techniques and the reasoning behind the antibacterial attributes of those composite materials.

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通过直接油墨书写技术开发具有杀菌特性的薄膜的最新进展和趋势。
随着各种因素导致的生存风险成倍增加,人们对治疗疾病、创伤和其他灾难的矫形假体、植入物和薄膜的需求也随之增加。考虑到需求的指数级增长,人们发现传统的移植物和膜技术在同时满足需求和提高效率方面已经落后。当增材制造(AM)作为假体、植入物和薄膜等医疗设备的替代制造技术出现时,传统方法所面临的这些挑战促使生物医学行业发生了革命性的转变。尽管这些技术快速而精确,但生物医学材料的主要特性是可加工性、杀菌性、生物相容性、生物降解性、无毒性以及良好的机械性能。目前,研究人员在材料方面面临的主要挑战是,定制材料虽然具有更好的机械性能和生物相容性,但却缺乏杀菌属性,而这在医疗保健领域也是首要的关键因素。因此,考虑到增材制造的优势和对具有杀菌特性的薄膜的需求,本综述将重点介绍主要使用直接油墨书写和一些增材制造技术制造具有抗菌特性的薄膜的研究,以及这些复合材料抗菌特性背后的原因。
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